Medically Reviewed by Dr. Vibhuti Rana, PhD and Dr. Atmika Paudel, PhD - Written by Dan Jackowiak Nc, HHP
Dr. Vibhuti Rana, PhD says... The article written below, discussing the anti-fungal activity of Microfase, in addition to the role of its ingredients is medically correct.
Microfase was developed after two years of research and pain staking testing of the proprietary herbal ingredients to be a stand alone yeast anti-microbial, or to be used in conjunction with Biofase and Profase.
The ingredients are sourced from all over the world and tested in our lab for activity and purity. Only the best antimicrobials were chosen for the final formula. These compounds have medically proven activity against candida and many strains of pathogenic bacteria and parasites.
After you review the ingredients below and the references to all the published medical studies, I think you will agree that Microfase would be a great addition to any yeast cleansing program.
Gymnema Sylvestre, a component of Microfase, has been typically used for the treatment of obesity and diabetes. As a matter of fact, a study in 2007 which was published in the Journal of Clinical Biochemistry and Nutrition, found the acids in the herb prevent the binding of carbohydrates to the receptors in the intestine and hence, the carbs are passed directly into the stool. Without the absorption of carbs into the blood stream, there is no blood sugar spike and no build up of fat cells from the storage of the excess sugar.1
It also helps to prevent cavities, has been used to treat asthma, eye problems, inflammation and does possesses antimicrobial properties.
Most importantly, this study done in 2013 found Gymnema Sylvestra inhibited Candida albicans from shifting from the yeast form to the pathogenic hyphael form. Candida yeast is much easier to kill in the yeast form verses the hyphael pathogenic form.
It also showed this ability prevent spores from shifting to hyphae in the fungi Aspergillus fumigatus. It was found to be non toxic to human and mamalian cells.2
Want to know what else gymnema sylvestre does, click here.
Microfase contains Caprylic acid, which is one of the three medium-chain fatty acids that is found in coconut oil. It is also found in palm oil, and the milk of humans and bovines in smaller amounts.
It’s been used to treat yeast infections, skin conditions, digestive disorders, and high cholesterol. It’s also used to lower the risk of antibiotic resistance. You can take caprylic acid orally or apply it to your skin.
There have been many studies published on caprylic acids effects on yeasts over the years. One such study that was published in 2017 showed it had an effect on the morphogenesis, adhesion, and biofilm formation of Candida albicans. It also had an effect on preventing C. albicans from forming hyphae, which has been said to be a more pathogenic form than spores.3
Another 2012 study found that capric acid and caprylic acid inhibited Candida mycelia growth at very low concentrations. The study was performed on animals with oral thrush caused by Candida albicans. The scientists found that capric acid-treated animals had
suppressed mycelial growth of the fungus on the tongue surface. The results suggested that caprylic acid has potential to support anti-Candida treatment.4
There are more studies on Caprylic acid on this webpage if you care to read them.
Berberine Sulfate typically comes from oregon grape root or the barberry plant. It has been typically used for eczema, gall bladder complaints, hepatitis B, gastritis and diarrhea. I added it to Microfase because it repeatedly tests well for Fluconazole resistant yeasts, which is a problem I see way too often.
In May of 2016, published in Antimicrob Agents Chemother, the the potential antifungal effect of berberine against fluconazole-resistant Candida and Cryptococcus neoformans strains, as well as against the biofilm form of Candida spp was studied. Analysis showed berberine damaged the plasma and mitochondrial membranes resulting in dna damage and cell death on both Candida and Cryptococcus neoformans. It also showed a significant reduction in biofilm formation activity.5
Front Microbiol published in Sept of 2016, that berberine was tested in combination with Fluconazole on Candida tropicalis. It was determined that berberine significantly reduced the ability of C. tropicalis to resist the fluconazole.6
Berberine was also found to be an effective agent against pathogenic E. coli as well as Candida, which proves it is antimicrobial.7
Berberine is also one of the compounds that is always tested on the stool tests I recommend. It usually rates high for effectiveness against both yeast and many strains of pathogenic bacteria. I felt this was a must have herb to add to Microfase.
I could go on and on here about the effectiveness of berberine on Candida and pathogenic bacteria. But I won't, if you care to read more studies here you go.
Microfase contains Oregano Extract from wild crafted oregano from the Mediterranean. Historical internal uses for oregano include colds, flu, and stomach upset. Externally it has been used for bronchitis, asthma, arthritis, muscular pain and lice.
In May of 2000, a report showed that a 6 week daily course of oregano could kill infections caused by the enteric parasites Blastocystis hominis, Entamoeba hartmanni and Endolimax nana.8 Symptoms associated with the infection are diarrhea, constipation, nausea, abdominal cramps, bloating, excessive gas, and anal itching.9 According to studies from Denmark, most cases of the infection appear to become diagnosed as irritable bowel syndrome.10 It has been estimated that 25% of the population in the United States is infected with this parasite. I don't doubt the 25% estimate, because I see Blastocystis hominis infections on stool test results all the time.
A published study in 2010 tested oregano oil on C. albicans, C. parapsilosis, C. krusei, C. lusitaniae, and C. dubliniensis. The oregano analysis showed 4-terpineol (47.95%), carvacrol (9.42%), thymol (8.42%) and terpineol (7.57%). The results suggested that a well blended oregano formula, not heavily weighted to carvacrol like most formulas, may represent an alternative treatment for candidiasis.11
A 2016 study using oregano extract against 30 different vaginal isolated strains of C. albicans in comparison to the drugs clotrimazole, fluconazole and itraconazole; showed that oregano was a more effective agent than clotrimazole. The oil affected the cell wall and membranes of the yeasts.12
One very important 2016 study showed oregano was not only more effective than the other herbs tested against Candida albicans, but also effective against Staphylococcus aureus and Pseudomonas aeruginosa.13 I see Pseudomonas aeruginosa occasionally on stool test results and do have personal experience with this biofilm building bacteria. If you have it, you need to get it under control asap, if it infects the lungs or the urinary tract and kidneys it can be fatal.
More published oregano studies can be found on this webpage.
There are more studies concerning oregano oil but they are also included with cinnamon bark extract, which is also in Microfase. Cinnamon has been typically used for digestive problems, constipation, rheumatic pain, and menstrual problems.
The anti-fungal activity of essential oils obtained from oregano, cinnamon, Mexican oregano, thyme, sage, rosemary, basil, and ginger were assessed against Candida glabrata. In addition, 30 fluconazole-susceptible C. glabrata isolates were also tested. Thyme, sage, rosemary, basil and ginger essential oils showed no antifungal activity. Both the oregano and Mexican oregano essential oils showed high levels of anti-fungal activity against the fluconazole-susceptible C. glabrata group, whereas the cinnamon essential oil showed the best anti-fungal activity against fluconazole-resistant C. glabrata.14
Recently, a research article published in 2017 found that cinnamon extract was active against fourteen gram-positive and gram-negative bacteria strains tested, including some antibiotic-resistant strains. It along with oregano extract were also effective against the H1N1 and HSV1 viruses and six different Candida strains. It was suggested that cinnamon extract would possibly work well for pneumonia causing S. pneumoniae as well.15
Just like bacterial sepsis, Candida in the blood stream is most often a death sentence if not treated promptly with high powered prescription drugs. In 2016, a study was done to determine if cinnamon oil would be effective for these types of infections caused by C. albicans, C. parapsilosis, and C. tropicalis. Cinnamon was found to be effective against 50% of the various Candida substrains, and 55% effective against C. krusei.16
There are more studies on cinnamon oil here if you care to take a look.
Grapefruit Seed Extract, GSE, has a long history as an anti-fungal and microbiocidal. In 2001 it was determined that GSE had anti-fungal activity on over 200 Candida albicans strains and 4 Candida spp strains isolated from patients with candidiasis symptoms. The study also showed it had low activity against dermatophytes and moulds.17
In 2004 it was determined that GSE had antimicrobial activity against 20 bacterial and 10 yeast strains with the strongest effects against Salmonella enteritidis.18
In 2012 GSE showed potent anti-fungal activity against S. cerevisiae, which I quite often see on stool test results. It induced cell death by destroying mitochondrial 60 S ribosomal protein, L14-A, and prevented the conversion of pantothenic acid to coenzyme A (CoA).19
More published medical studies for gse can be reviewed on this webpage.
According to the Encyclopedia of Herbs, Neem leaf has been used to reduce inflammation, clearing toxins, and lowering fevers. It destroys a wide range of parasitic organisms and is insecticidal. It has been used internally for malaria, tuberculosis, arthritis, rheumatism, and intestinal worms. Externally it works well for ringworm, eczema, lice, fungal infections, and muscle and joint pain.
In 2015 Neem leaf was tested against the pathogenic bacteria Streptococcus mutans, Enterococcus faecalis, Staphylococcus aureus and Candida albicans and their biofilms. It was discovered that Neem leaf had considerable antimicrobial activity against all these pathogens.20
Another study published in 2017 tested on 216 different samples of Candida albicans and Streptococcus mutans showed that Neem leaf had considerable antimicrobial effects against both pathogens.21
More published medical studies for neem leaf can be reviewed on this webpage.
I could go on and on here with the studies but at this point, I think you have to agree that Microfase is a potent anti-fungal and antimicrobial product. But if not, you can always go over to Pubmed and read some more on any of these ingredients.
The best way to use Microfase is to take it with Biofase and Profase. Biofase strips the biofilms, Microfase directly kills the pathogens, and Profase cleans up the remaining mess.
I would take Biofase and Profase 1 hour or
more before breakfast and 30 minutes before bedtime. Take Microfase 30
minutes after the Biofase, Profase combination. Or, take as suggested and Microfase 30 minutes before breakfast and dinner.
If taking Microfase by itself, I would take to 2 capsules 30 minutes before meals 2 to 3 times daily. It would probably be best to start with 2 capsules twice a day, breakfast and dinner and after a week add 2 caps at lunch.
Microfase is currently available at this website either in single bottles or a Kit with Biofase and Profase.
You can also find it on Amazon.
Dr. Vibhuti Rana, PHD says...
The article written above, discussing the anti-fungal activity of Microfase, in addition to the role of its ingredients is correct.
The potent anti-fungal and bactericidal roles of Gymnema sylvestre, Berberine sulfate, undecylenic acid, grape seed extract, neem extract, oregano oil, and cinnamon have been elaborated in literature and are very important for Ayurveda based treatments too. These herbs have been used in ancient medicinal practices for thousands of years and I believe that the best treatment for fungal infections starts with enzymes, herbal antifungals, and probiotics.
Dr. Atmika Paudel, PhD says...
The above article is about a product called Microfase that is said to contain different herbs. The facts about the herbs mentioned in the article are correct. The article is well written and provides a wealth of information about the beneficial effects of the herbs and compounds that are used in the product Microfase. All the information are evidenced with scientific literature. The information looks up to date with recent findings.
Microfase contains seven different major ingredients that have beneficial effects against yeast and its biofilm. In addition, they have good effects to human health and have been used for man other ailments traditionally. The ingredients such as Gymnema sylvestre, caprylic acid, cinnamon bark, oregano extract, grapefruit seed extract, neem all are naturally occurring and familiar to us in one way or another. The formulation looks a good combination of components that are harmful to bacteria and fungi and most of them have been used as traditional medicines, therefore, their safety is already assessed.
Do you have any questions about Microfase or yeast infections in general? Ask your question here or contact us using the contact page of this website. It is also always a good idea to talk to your doctor as well.
Click below to see questions from other visitors to this page...
When would be best time to take Microfase?
When would be best time to take Microfase? Would I reduce the number of Biofase and Profase?
What type of cinnamon is in Microfase? (Cassia or Ceylon)
Some people may be reactive to one kind but not the other.
Can Microfase be taken before lunch instead of before breakfast when also taking biofase/profase?
Can Microfase be taken before lunch instead of before breakfast when also taking Biofase/Profase?
These supplements have given me my life
back twice now. I got very ill when Microfase went out of stock. I
tried numerous other yeast management protocols, spending tens of
thousands of dollars with no avail. I'm on the upswing once again
after increasing to 3 times a day as I had forgotten that I had
gotten so healthy I was able to wean down the Microfase before.
These products have saved my life and put a stop to hopelessness and
terrible suffering. I am truly grateful and hope you never run out
Thank you so much,
Herbal Yeast Infection Remedies Home
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2. PLoS One. 2013; 8(9): e74189. Published online 2013 Sep 11. doi: 10.1371/journal.pone.0074189
PMCID: PMC3770570 Gymnemic Acids Inhibit Hyphal Growth and Virulence in Candida albicans
3. Jadhav A, Mortale S, Halbandge S, et al. The Dietary Food Components Capric Acid and Caprylic Acid Inhibit Virulence Factors in Candida albicans Through Multitargeting. J Med Food. 2017;20(11):1083-1090. doi:10.1089/jmf.2017.3971
4. Takahashi M, Inoue S, Hayama K, Ninomiya K, Abe S. Med Mycol J. 2012;53(4):255-261. doi:10.3314/mmj.53.255
5. Antimicrob Agents Chemother. 2016 May 23;60(6):3551-7. doi: 10.1128/AAC.01846-15. Print 2016 Jun.
Berberine Antifungal Activity in Fluconazole-Resistant Pathogenic Yeasts: Action Mechanism Evaluated by Flow Cytometry and Biofilm Growth Inhibition in Candida spp.
6. Front Microbiol. 2016 Sep 23;7:1516. eCollection 2016. Antiproliferation of Berberine in Combination with Fluconazole from the Perspectives of Reactive Oxygen Species, Ergosterol and Drug Efflux in a Fluconazole-Resistant Candida tropicalis Isolate.
7. Microb Pathog. 2017 Jan;102:12-20. doi: 10.1016/j.micpath.2016.11.011. Epub 2016 Nov 23. Breaking the resistance of Escherichia coli: Antimicrobial activity of Berberis lycium Royle.
8. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Force M et al. Phytother Res. (2000)
9. "Division of Parasitic Diseases - Blastocystis hominis Infection Fact Sheet". Cdc.gov. 2008-06-06. Retrieved 2010-04-04.
10. Stensvold CR, Lewis HC, Hammerum AM, et al. (November 2009). "Blastocystis: unravelling potential risk factors and clinical significance of a common but neglected parasite". Epidemiol. Infect. 137 (11): 1655–63. PMID 19393117. doi:10.1017/S0950268809002672.
11. Braz J Microbiol. 2010 Jan;41(1):116-23. doi: 10.1590/S1517-838220100001000018. Epub 2010 Mar 1.
In vitro activity of origanum vulgare essential oil against candida species.
12. J Appl Microbiol. 2016 Dec;121(6):1530-1545. doi: 10.1111/jam.13282. Epub 2016 Oct 24.
Sensitivity of Candida albicans to essential oils: are they an alternative to antifungal agents?
13. J Infect Dev Ctries. 2016 May 31;10(5):494-505. doi: 10.3855/jidc.7610. Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms.
14. J Mycol Med. 2015 Sep;25(3):213-7. doi: 10.1016/j.mycmed.2015.06.003. Epub 2015 Aug 14.
In vitro activity of essential oils extracted from condiments against fluconazole-resistant and -sensitive Candida glabrata.
15. Microbiologyopen. 2017 Mar 14. doi: 10.1002/mbo3.459. [Epub ahead of print] Antibacterial, antifungal, and antiviral effects of three essential oil blends.
16. J Clin Diagn Res. 2016 Aug;10(8):DC09-11. doi: 10.7860/JCDR/2016/19958.8339. Epub 2016 Aug 1.
Antifungal Activity of Cinnamon Oil and Olive Oil against Candida Spp. Isolated from Blood Stream Infections.
17. Wiad Parazytol. 2001;47(4):845-9. [Effects of 33% grapefruit extract on the growth of the yeast--like fungi, dermatopytes and moulds].
18. Acta Pharm. 2004 Sep;54(3):243-50. Antimicrobial activity of grapefruit seed and pulp ethanolic extract.
19. PLoS One. 2012;7(3):e32943. doi: 10.1371/journal.pone.0032943. Epub 2012 Mar 5.
A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast.
20. J Conserv Dent. 2015 Nov-Dec;18(6):461-6. doi: 10.4103/0972-0707.168810.
Antibacterial efficacy of Azadirachta indica, Mimusops elengi and 2% CHX on multispecies dentinal biofilm.
21. J Clin Diagn Res. 2017 May;11(5):ZC97-ZC101. doi: 10.7860/JCDR/2017/23784.9950. Epub 2017 May 1.
Efficacy of Neem Extract and Three Antimicrobial Agents Incorporated into Tissue Conditioner in Inhibiting the Growth of C. Albicans and S. Mutans.
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