Dr. Atmika Paudel, PhD says... The facts in the article below about Gymnema sylvestre effects on yeast infections and its possible safety issues are correct and evidenced with experimental medical reports.
Gymnema sylvestre is an herb that is native to India and has been
traditionally used to treat diabetes, metabolic syndrome, weight loss,
and coughs. It has also been used to treat malaria and as a snake bite
antidote, digestive stimulant, laxative, appetite suppressant, and
diuretic. It is believed to have the unique ability to reduce a
person's craving for sweets, which is extremely useful for a person just
starting out on the candida yeast diet.
In addition to the studies on the Microfase page, which proves Gymnema sylvestre has the ability to prevent the production of spores by candida hyphae, and promotes the conversion of candida hyphae back into yeast spores which are much easier to kill, it has a broad spectrum of activity against other pathogens.
In a 2017 study that was performed by Microbiologists Arora and Sood from the Department of Microbiology at Guru Nanak Dev University in India, using the leaves against 13 Gram negative and Gram positive pathogenic bacteria, it was established that its broad spectrum activity had an average inhibition zone ranging from 14 to 23 mm. Candida albicans was the most sensitive organism, with an inhibition zone ranging from 13 to 35 mm. The flavonoids in the herb were the most effective with a kill time of 0-8 hours. The study concluded that Gymnema sylvestre was of clinical importance for Pseudomonas aeruginosa, Candida albicans, Escherichia coli, Staphylococcus aureus, and more. It was also neither mutagenic nor cytotoxic to the body.(Source)
It also has an immune modulating effect and stimulates the lymphoid components of immune system.(Source) This is helpful to remove any toxins released by the death of candida yeast cells in the body.
Another study performed on mice with carcinogenic tumors, it was noted that it had marked antitumour-promoting activity and anti-inflammatory effects.(Source)
A study published in Biomed Res Int. in 2014, found that the "herb exhibits a broad range of therapeutic effects as an effective natural remedy for diabetes, besides being used for arthritis, diuretic, anemia, osteoporosis, hypercholesterolemia, cardiopathy, asthma, constipation, microbial infections, indigestion, and anti-inflammatory. G. sylvestre has good prospects in the treatment of diabetes as it shows positive effects on blood sugar homeostasis, controls sugar cravings, and promotes regeneration of pancreas. The herbal extract is used in dietary supplements since it reduces body weight, blood cholesterol, and triglyceride levels and holds great prospects in dietary as well as pharmacological applications".(Source)
In another study, Aleisa and colleagues published the effect of gymnema on mice with ulcerative colitis in the Journal of the International Society for Complementary Medicine Research. The scientists measured the inflammatory markers present in the mice with the disease to establish a baseline. Another group was administered Gymnema before they pre-induced ulcerative colitis and inflammatory markers were measured 24 hours later. G. sylvestre inhibited the development of ulcerative colitis and resulted in a reduced mucus content.
Enzymatic activities of the antioxidant enzymes superoxide dismutase and catalase were brought back to their normal levels. A significant reduction in DNA, RNA and TP inflammatory levels were eliminated by the treatment. It inhibited the elevation of pro-inflammatory cytokines, PGE2 and NO levels in the colon. The apparent UC protection was further confirmed by the histopathological screening. It was determined that G. sylvestre extract showed significant amelioration of experimentally induced colitis.(Source)
Dr. Vibhuti Rana, PhD says...
Gymnema sylvestre, or “Gurmar” (sugar destroyer) vernacularly, also known as Australian cowplant, and Periploca of the woods, is an herb with vast pharmacological importance. In Ayurveda, it is believed that the phytoconstituents (triterpene saponins known as gymnemic acids, gymnemasaponins, and a polypeptide, gurmarin) of this herb suppress the sugar/glucose levels in the body. The herbal extract of G. sylvestre has been used for the body weight lowering of body weight, reducing blood cholesterol the triglyceride levels, amongst various pharmacological uses (1).
In another study, in vitro studies on human adenoma colon cancer cell lines were done using silver nanoparticles that were biofunctionalized with aqueous extracts of G. sylvestre and it was shown that the anti-cancer properties of the G. sylvestre constituents can be enhanced upon biofunctionalization (2). These bio-synthesized silver nanoparticles also exhibited effective antifungal activity against Candida albicans, Candida nonalbicans and Candida tropicalis (3).
What’s more, the anti-stress, anti-allergic, and antiulcer activity of the bioactive ingredients of G. sylvestre have been analyzed and demonstrated in another report. Experiments, including histopathology showed gastric protection against the aspirin-induced gastric ulcer mice model (4).
G. sylvestre, or madhusnashini, is available as tea bags, tablets, supplements for use in a number of medical complications including diabetes, asthma, obesity, arthritis, osteoporosis, constipation, and as an anti-inflammatory agent (5). It is of great use in developing countries due to its wide abundance and ayurvedic recognition.
The only known side effect is a reduction in blood sugar levels which could be a concern for people on diabetes medications. If you are diabetic, please consult with your doctor before taking gymnema for your yeast infection.
There are many more studies out there on gymnema, but the above is what I feel are the most important. With the effect of reducing a persons craving for sweets so you don't keep feeding the yeast, while preventing the production of spores by candida while forcing the hyphael pathogenic form back into a much easier to kill spore form, everyone with a chronic candida yeast problem should take it.
Dr. Vibhuti Rana, PhD says...
By now, it is quite evident that G. sylvestre, taken in any form, can reduce our sugar cravings and facilitate faster combating of fungal/yeast infections since sugar is the main food for yeast. In essence, the gymnemic acids have been shown to inhibit the formation of invasive hyphae from C. albicans-infected Caenorhabditis elegans worms, saving them from C. albicans induced death (1). Apart from the numerous direct health benefits this article has already discussed, it indirectly inhibits the yeast or hyphal growth of Candida and its other species, helping to detox the body from this pathogen.
The facts in the above article are correct and convincing as they have been evidenced with experimental reports. According to a paper published in PLOS One in 2013, gymnemic acids, present in the leaves of Gymnema sylvestre, inhibit yeast to hyphae transition of Candida albicans, although gymnemic acids did not have effect on the growth and viability of Candida. (1) Gymnemic acids rendered C. albicans less virulent in a nematode infection model, and also inhibited the hyphal growth of another fungi Aspergillus in the same study.
Another study found that the aqueous extract of Gymnema sylvestre had potent antifungal activity against Candida albicans and antibacterial activities against Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, and Sigella flexneri (2)
Gymnema sylvestre has other several pharmacological properties including wound healing property (3) , hepatoprotective property (4) , immunomodulatory activity (5) , antidiabetic activity (6) , anti-inflammatory activity with less gastric toxicity (7) , anti-arthritic activity (10)
The role of dietary carbohydrates have been shown to increase the risks of Candida infections (9) (10) and Gymnema sylvestre have shown to reduce sugar cravings. (11)
Thus, G. sylvestre is indirectly involved in decreasing the risk factor of Candida infection in addition to the direct involvement by inhibiting Candida growth and transition from yeast form to hyphal form, and rendering Candida less virulent.
Gymnemic Acids Inhibit Hyphal Growth and Virulence in Candida albicans.
Govindsamy Vediyappan, Vincent Dumontet, Franck Pelissier, Christophe
d’Enfert. PLOS. September 11, 2013
2. Arora, D.S., Sood, H. In vitro antimicrobial potential of extracts and phytoconstituents from Gymnema sylvestre R.Br. leaves and their biosafety evaluation. AMB Expr 7, 115 (2017) doi:10.1186/s13568-017-0416-z
4. In Vitro and in Vivo Evaluation of Hepatoprotective Activity of Gymnema Sylvestre. International Journal of Pharmaceutical Sciences and Nanotechnology. Volume 2, Issue 4, March 2010
5. Immunomodulatory activity of gymnema sylvestre R.Br. Leaves on in-vitro human neutrophils.Jitender K Malik1*, Dr.F.V. Manvi1, Dr.B.K.Nanjwade, Dr. K.R. Alagawadi,Sanjiv Singh1. Department of Pharmaceutical Chemistry, K.L.E.S’s College of Pharmacy, Belgaum.(KA)Accepted on: 20-06-2009
6. Hypoglycemic Activity of Gymnema sylvestre Extracts on Oxidative Stress and Antioxidant Status in Diabetic Rats Myung-Hwa Kang, Min Sun Lee, Mi-Kyeong Choi, Kwan-Sik Min, and Takayuki Shibamoto. Journal of Agricultural and Food Chemistry 2012 60 (10), 2517-2524 DOI: 10.1021/jf205086b
7. Diwan, P.V., Margaret, I. & Ramakrishna, S. Influence of Gymnema sylvestre on inflammation. Inflammopharmacology 3, 271–277 (1995) doi:10.1007/BF02659124
8. Anti-arthritic activity of leaves of Gymnema sylvestre R.Br. leaves in rats. Jitender K Malik1,2*, F. V. Manvi1, B. R. Nanjware1, Deepak Kumar Dwivedi2, Pankaj Purohit2, Sandeep Chouhan2 1Department of Pharmaceutical Chemistry, K.L.E.S's College of Pharmacy, Belgaum (KA) 2R. D. Memorial College of Pharmacy, Bhopal (MP), India Der Pharmacia Lettre, 2010: 2 (1) 336-341
9. Dr Khaled H. Abu-Elteen (2005) The influence of dietary carbohydrates on in vitro adherence of four Candida species to human buccal epithelial cells, Microbial Ecology in Health and Disease, 17:3, 156-162, DOI: 10.1080/08910600500442917
10. Journal of Medical Microbiology Volume 15, Issue 4. The Effect of Dietary Carbohydrates on the In-vitro Adhesion of Candida Albicans to Epithelial Cells Free. L. P. Samaranayake and T. W. Macfarlane. First Published: 01 November 1982
11. Mishra, Bharat & Pancholi, s.s & Deshmukh, Aaishwarya & Panjwani, Dharamveer. (2012). Preclinical investigations of a novel dose Regimen based on the combination of pioglitazone and Gymnema sylvestre extract. Mol Clin Pharmacol. 2. 20-33.
Gymnema Sylvestre is found in Microfase
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