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Candida Yeast Enzyme Review: The Best and The Worst

Updated 1/4/2020

Medically reviewed by Dr. Atmika Paudel, PhD - Written by Dan Jackowiak Nc, HHP and Dr. Vibhuti Rana PhD

Dr. Atmika Paudel, PhD says... The comparison information presented here about candida yeast enzymes and their safety is medically correct.

In order to get the full understanding of how these candida yeast enzymes work, it is best that you go read the "Enzymes for Yeast" page that can be accessed from the main menu under Treatment, Enzyme Therapy.

Reading the "Structure of Candida" under The Basics tab would be a good idea as well.

If you've already done your research and just want to know what the best enzymes are for treating yeast infections, read on.

Inferior Candida Yeast Enzymes

There are many Candida yeast enzymes for yeast formulas on the market today but take a look at the four most popular.

  • Candex
  • Candizyme
  • Candidase
  • Candifense
  • There are others, but most are slightly different variations of the above products.

Candex contains cellulase, hemicellulase, amylase, invertase and glucoamylase. It does not contain any protease to eat the mannoproteins and nucleus, lipase to eat the fatty acid lipids, or serrapeptase or serratiopeptidase to eat the fibrinogen in the biofilm.

Because Candex does not contain a fibrinogen, protein or fat eating enzyme it is therefore incomplete and would not be my first choice.

Candidase contains a Cellulase Thera-blend to eat the cell wall and a Protease Thera-blend™ to eat the protein components. The quantities of enzymes per dose are very high, especially the protease, which has been said to minimize any die-off reactions. However, this formula is incomplete, there are no enzymes to eat the polysaccharides, lipids, or fibrinogen in the biofilm.

Candizyme contains cellulase and hemicelluse that eats the biofilm and cell wall.  Protease to eat the mannoproteins and nucleus and the starch eating enzymes lysozyme, amylase, lactase, malt diastase and glucoamylase to help with the polysaccharides in the biofilm. This is a pretty good formula for breaking through the biofilm and eating the cell wall of candida yeast. However, Candizyme lacks an enzyme that eats the fibrinogen in the biofilm, or an enzyme that eats the fatty acid lipids so it is also incomplete.

Candifense contains cellulase, hemicellulase, amylase, invertase, xylanase and beta-glucanase. The enzyme amounts are very close to Candex. It does not contain protease to eat the mannoproteins and nucleus, lipase to eat the fatty acid lipids, or serrapeptase to eat the fibrinogen in the biofilm. Like the other enzyme formula's it is incomplete.

How Enzymes for Yeast Work

Studies show that when enzymes attack the cell wall of Candida yeast it begins to scramble and beef up its cell wall structure. It will beef up the cell wall with parts that are not under attack, which results in not being able to get rid of the over growth. You will probably have some relief but in order to maintain the health gains you've made, you will have to continue taking them indefinitely.

Proteins make up 55% of the cell wall structure and biofilm as well so the enzyme formula must contain a protein digesting enzyme such as protease.

Not only do yeasts use fibrin and fibrinogen in the biofilm, but they also use it as an attachment mechanism to attach to your intestinal wall. By using an enzyme formula with serrapeptase, you are cleaning all of the biofilm away, which allows your good bacteria to attach to these spaces. The newly formed bacterial colonies will not allow the yeasts to re-attach to your intestinal wall.... the result is, eventually you will be back to normal and will not have to take supplements for the rest of your life to control the over growth.

If I was going to use any of the above four enzyme formulas, I would take it with SerraEnzyme so you have an enzyme that will eat the fibrinogen and ligands in the biofilm.

Superior Candida Yeast Enzymes

Biofase for yeast is very similar to the four enzyme formulas below. It contains cellulase, hemicellase and beta-glucanase to eat the glucan and chitin component in the biofilm and yeast cell. Glucoamylase, amylase and invertase to eat the polysaccharides in the biofilm and cell wall. Protease to eat the polypeptides of the biofilm, mannoproteins and nucleus of the yeast cell. Lipase to eat the fatty acid lipids, and also includes a serrapeptase enzyme that eats the fibrinogen of the biofilm making it a complete yeast eating enzyme.

Serrapeptase also goes into the blood stream and cleans the blood of dead tissue, blood clots, plaque, cysts, fibrin and other unwanted microbes. It also helps reduce inflammation.

Yeast and Candida have a very hard time adapting to these enzymes for yeast just like they do to bacteria but they do indeed attempt to do so by scrambling their cell wall structure. They will beef up the components of the cell wall not under attack in order to survive, that's why it is so important to take a complete formula that attacks all the pieces of the cell wall.

The enzymes will boost the effects of prescription medications like Diflucan because Diflucan cannot remove the biofilm. Diflucan can cause yeast and Candida to shape shift and become a resistant strain like Candida glabrata and Candida krusei. Both of these yeasts are highly resistant to Diflucan and are very hard to get rid of. But by stripping the biofilm with enzymes first, the success rate of using Diflucan increases significantly the first time, which helps prevent shape shifting and relapses.

Dr. Vibhuti Rana, PhD says...

Though I cannot comment on the individual enzyme formulas mentioned in the article, I agree with the mechanisms behind which they work. Fungal biofilms comprise of polysaccharides, networking proteins of the extracellular matrix, and lipids or fatty acids. It is formed by a number of Candida species such as Candida albicans, C. krusei, C. guilliermondii, C. lusitaniae, and C. tropicalis. For any formula to work successfully, the enzymes need to work at all the levels of microbial biofilm construction-carbohydrate, proteins, and fats. Once the biofilm is broken down, the Candida yeast becomes susceptible to elimination by the immune system of the host, and flourishes the good bacteria in the gut (1, 2).

Serrapeptase is a proteolytic enzyme that has a significant role in breakdown of the networking proteins due to their fibrinolytic (fibrinogen digesting) properties. It has wide applications in reducing inflammation and infections where microbial films play a major role, e.g transplant-associated infections (3). Nattokinase, which destroys amyloid in biofilms, and serrapeptase, which digests fibronectin, are key enzyme molecules which facilitate the access of antifungal drugs at the site of infection (4).

As mentioned above, once the biofilm, which acts like the safe haven to hazardous infections fungal and bacterial species, is stripped off, the antifungal drugs manifest their action and give effective results.

  2. Bizerra FC, Nakamura CV, de Poersch C, et al. Characteristics of biofilm formation by Candida tropicalis and antifungal resistance. FEMS Yeast Res. 2008;8(3):442-450. doi:10.1111/j.1567-1364.2007.00347.x.

Candida Enzymes Price Comparison

Candex costs about $47.99 or 40 cents per capsule for 120 capsules, add SerraEnzyme for $19.00 for a total of $66.99.

Candidase runs about $40.12 or 48 cents per capsule for 84 capsules, plus the $19.00 for SerraEnzyme equals $59.12.

Candizyme costs about $35.00 for 90 capsules plus the $19.00 for SerraEnzyme costs you $54.00.

Candifense costs $69.97 for 120 capsules which amounts to 58 cents per capsule, this is on of the most expensive enzyme formulas on the market. Add SerraEnzyme for $19.00 and it costs you $88.97.

A Biofase 90 capsule bottle is only $39.95, or 44 cents per capsule. A bargain when you consider you don't have to buy SerraEnzyme because serrapeptase, along with all the other enzymes required to eat the cell wall and biofilm, are in the formula.

Biofase is also offered in a 180 capsule bottle for $67.95 or 38 cents per capsule, which lowers your expense to $33.97 per 90 capsules if you choose this bottle size.

Candida Yeast Enzymes vs Digestive Enzymes

I get asked quite often if digestive enzymes would work as well as a yeast eating enzyme because they are cheaper, and generally contain the very same enzymes as an enzyme for yeast, so here's a comparison.

candex label

The label on the right is from a 120 capsule bottle of Candex. The enzyme amounts are per two capsules so lets narrow this down to one capsule.

Cellulase 32,000 cu
Hemicellulase 20,000 hcu
Amylase 2000 skb
Invertase 500 su
Glucoamylase 100 ag

Notice the large amounts of cellulase and hemicellulase. All yeast eating enzymes will contain these in large amounts because of the glucan, chitin and cellulistic plant matter in the biofilm and cell wall, (membrane), of Candida yeast.

digestive enzyme label

The next label is from a Doctors Best Digestive Enzyme formula and ingredients listed are per one capsule. Although this formula is heavy on protein digesting enzymes and has a broad range of sugar digesting enzymes, the glucan, chitin and cellulistic plant matter digestive enzymes are insufficient. The amounts are:

Cellulase is 3250 cu
Hemicellulase is 750 hcu

Candex has over 10 times the amount of cellulase and 26 times the amount of hemicellulase. You will find all enzymes for yeast contain these high amounts because it is required to have any success at clearing yeast infections.

Biofase Verses It's Closest Competitor

In my opinion, Biofase's closest competitor is Klaire Labs Interfase so lets do an honest comparison.


Comparing the label of Interfase to Biofase we see very similar enzyme profiles with Interfase having Chitosanase where Biofase does not.

However, we have tested the Cellulase and Hemi-cellulase enzymes in Biofase and they do show Chitosanase side activity.

Chitosanase digests the very same thing as Cellulase and Hemicellulase so it really is not needed. As a matter of fact, chitin and cellulose are both made from glucose monomers, or monosaccharides, but instead of a hydroxyl group, the glucose molecules in chitin have an amyl group attached that consists of carbon and nitrogen. Cellulase and Hemicellulase digest it very effectively.

We also see that Interfase does not contain a fat digesting enzyme for the yeast cell wall where Biofase does in the form of Lipase.

We also see that each capsule is 425mgs.


If we click on the link above for Interfase we see that it currently sells for $52.95 on Amazon for 120 - 425mg capsules, total mgs per bottle is 51000. Per capsule cost is .441 cents.

Looking at the label for Biofase we see each capsule contains 525mgs so Biofase per capsule is stronger than Interfase. Total milligrams per 120 capsules is 63000.

Biofase comes in both a 90 capsule bottle and a 180 capsule bottle with the 180's costing $67.95. That's .377 cents per capsule so a 120 capsule bottle, if there was such a thing, would cost $45.24. And... you are getting more milligrams and a stronger formula.

Dr. Vibhuti Rana, PhD says...

The above information regarding the enzyme formulations for different yeast biofilm-digesting enzymes is correct. The enzyme compositions for the two products compared above are quite similar. Hemicellulase and cellulase have a high anti-biofilm activity and work well for a number of fungal and bacterial species, like Candida species, P. aeruginosa and K. pneumoniae. Likewise, chitosanase works in the same manner for a number of Gram positive and Gram-negative species of biofilm producers (1, 2). Therefore, selecting the formula which gives you maximum benefit at an optimum price would be the best step towards getting rid of Candida biofilm species’ biofilms. Moreover, when complemented with the use of antifungal drugs like amphotericin B, azole-class drugs, echinocandins, etc. will completely eradicate the infections.

  1. Muslim SN, Al-Kadmy IMS, Hussein NH, Mohammed Ali AN, Taha BM, Aziz SN, Kheraif AAA, Divakar DD, Ramakrishnaiah R. Chitosanase purified from bacterial isolate Bacillus licheniformis of ruined vegetables displays broad spectrum biofilm inhibition. Microb Pathog. 2016 Nov;100:257-262. doi: 10.1016/j.micpath.2016.10.001. Epub 2016 Oct 8. PMID: 27725283.
  2. Asli A, Brouillette E, Ster C, Ghinet MG, Brzezinski R, Lacasse P, Jacques M, Malouin F. Antibiofilm and antibacterial effects of specific chitosan molecules on Staphylococcus aureus isolates associated with bovine mastitis. PLoS One. 2017 May 9;12(5):e0176988. doi: 10.1371/journal.pone.0176988. PMID: 28486482; PMCID: PMC5423679.

D&G Industries also offers a 10% off Loyalty program for all orders after the first if you leave a review on the store website. That makes that $45.24 per 120 capsules turn into $40.71 ;)

You may have noticed that both Biofase and Interfase are Proprietary blends and list their enzymes in milligrams verses the specific enzyme activity of other brands. Proprietary refers to a patent, or ownership. Applying this to Biofase and Interfase, it means each company owns the rights to their specific blend of enzymes, making these products different from similarly marketed systemic enzyme supplements. This is not done to hide anything but does help to prevent foreign copycats. It's also meant to hopefully make the decision of choosing a product easier by simplifying what the product is and what it is intended to do.

In all honesty, listing enzyme activity levels for any blended enzyme formula is meaningless. No one can tell you what 32,000cu of cellulase is going to do in the body, or what 80,000spu's of serrapepetase is going to do either. In single enzyme formulas it can help to determine what's a better buy. But in blended formulas, all that matters is if it works or not. Biofase is formulated to work, which is all that matters, this is what Dave has to say:

Hi Dan,

Please post this testimonial on your website.

I have been suffering with systemic candidiasis for around 7 years and anyone who has been dealing with the same problem knows it is quite different than a yeast infection and extremely hard to get rid of. For years I have been taking Candex and it has helped but it has not eliminated my candida. Two weeks ago I decided to try Biofase for yeast and I have noticed a huge difference, it is head and shoulders above Candex. I would compare Candex to a handgun and Biofase to a bazooka and believe me when combating candida you want the bazooka as this disease is extremely ruthless. From here on out I will be ordering Biofase. Thank you Dan for all your research that has gone into making this product!


There are enzyme medical studies with testimonials from real people on this webpage about Biofase, and more testimonials here if you care to read them. There are also testimonials on this store website along with a Star rating. Biofase is also rated 4.5 Stars on Amazon.

Are Candida Yeast Enzymes Safe to Take?

Yes. There are no known toxicity issues with any of these enzymes for yeast.

As a matter of fact, in the book, Enzymes: The Fountain of Life by K. Miehlke, R. M. Williams, D. A. Lopez; they reference studies done on rats and guinea pigs and observed no ill effects at daily doses that are equivalent to 250 capsules a day for a 134 pound person.

In another study, rats were fed the equivalent of 2500 capsules a day daily for a short period and the rats only seemed a little fatigued. Research has also looked at cell changes and mutations. They found no negative affects at all.

They have been given GRAS status by the FDA.

What are the possible side effects of enzymes for Candida yeast?

In our experience, in highly toxic individuals with high levels of yeasts or bad bacteria, it is entirely possible to have a cleansing reaction.

These people may experience nausea, a “burning sensation” in the stomach, or abdominal cramping. This is because the enzymes may aggravate pre-existing problems in the GI tract, basically they are working. If this occurs, I suggest using one half of a capsule, twice daily, emptied into eight ounces of warm water, and building up from there. To avoid this problem to start with take one capsule the first three days, two capsules day four through six, and so on, until you reach the recommended daily dose.

Many people that have the stomach pains have found that if they stop taking them altogether for a couple of days, then start back up at a lower dose, they don't have anymore problems.

Another method that works well is to take a probiotic that is designed to kill yeast, such as Profase, for a week or two prior to taking the enzymes.

Enzymes that do attack all the components of the cell wall can also cause the yeast to release spores in an effort to survive, which makes the infection worse. If this happens to you the best thing to do is raise the dose, or add herbs and probiotics to help nock it down as quick as possible. Quite frankly, the best way to treat these infections is with all three; enzymes, herbs and probiotics.

How to Take Candida Yeast Enzymes

The Best way is to incorporate them into a this 3-Step Treatment Plan here.


Many times when using enzymes for yeast, a change in diet is not needed if the yeast infection is mild. However, it makes sense to not feed the yeast when you are trying to get rid of it. Why give it something to fight back with? It just doesn't make sense does it?

Generally, I would follow the directions on the label. But it is important to take these enzymes at least one hour or more before breakfast and at bedtime. You don't want to take them with food or any supplements that contain fiber because the enzymes will digest those and not do what you want them to do.

These enzymes for yeast infections are safe for children and the recommended dose is one-half capsule, twice daily, for each 40 pounds of body weight. However, I can't speak for the other enzymes above, but I have one year olds taking one Biofase with one Profase twice a day with very good results. For ages 14 and up, adult recommendations may be followed.

It is best to take them away from food, one hour or more before breakfast and at bedtime.

Medical Review by Dr. Atmika Paudel, PhD

This is not an endorsement of the products and I do not want to comment upon the comparisons of the products mentioned in the article, but to the best of my knowledge the active constituents that the yeast enzyme contains such as cellulase, hemi-cellulase, invertase, protease, lipase, and amylase fall under the Generally Recognized As Safe (GRAS) category of the U.S. Food and Drug Administration (FDA), when they are derived from the source mentioned by FDA.

Cellulase is known to disrupt the biofilms of microorganisms, which are generally difficult to penetrate through by antibiotics. Although yeast cell wall contains chitin instead of cellulose in plant cell, cellulase, hemicellulase, lysozyme, pectinase, and alpha amylase are non-specific enzymes and have been used for breaking down chitin (1).

Fibrinogen and fibronectin are components of human body that have important functions in wound healing and blood clotting. Microorganisms such as bacteria and yeast use fibrinogen and fibronectin to adhere and make biofilms with the help of fibronectin binding proteins present in these microorganisms. Therefore, appropriate caution should be taken when taking products containing enzymes whose long-term safety are not well-known. Another important factor to be cautious is taking other medications together with the enzymes- for example- serratiopeptidase may interact with medications used for blood thinning purposes.

1. Advances in Food and Nutrition Research. Volume 65, 2012, Pages 321-336 Chapter 21 - Chitooligosaccharides as Potential Nutraceuticals: Production and Bioactivities

Have Any Questions About Candida Yeast Enzymes?

Do you have any questions about any of these Candida yeast enzymes or yeast infections in general? Ask your question here or contact us using the contact page of this website. It is also always a good idea to talk to your doctor as well.

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