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Candida Yeast Enzyme Review: The Best and The Worst

Updated 5/26/2023

Medically reviewed by Dr. Atmika Paudel, PhD - Written by Dan Jackowiak Nc, HHP and Dr. Vibhuti Rana PhD

Dr. Atmika Paudel, PhD says... The comparison information presented here about candida yeast enzymes and their safety is medically correct.

Biofilm & Cell Wall Structure Review

Mannoproteins make up 55% of the yeast cell wall and biofilm structure. Typically, these mannoproteins will be 20% protein and 80% mannose polysaccharides. Inside of the cell wall structure is the nucleus which is composed of proteins and fats. In order to completely break down the protein part of the biofilm and nucleus, the enzyme formula must contain a protein digesting enzyme such as protease.

25% of the biofilm is a carbohydrate rich matrix composed of polysaccharide carbohydrate glucans and chitins. The cell wall also contains these components. These can be removed by the enzymes cellulase, hemicellulase, beta-glucanase, amylase, invertase, glucoamylase and a few others.

15% of the biofilm and cell wall structure is composed of lipids or fats, which can be removed with an enzyme such as lipase.

Nucleic acids make up 5% of the structure and contain dna and rna material.

Yeasts also use fibrin and fibrinogen in the biofilm and as an attachment mechanism to attach to your intestinal wall. Serrapeptase digests this component and in doing so, it detaches the biofilm from the intestinal wall, which allows your good bacteria to attach to these spaces. These newly formed bacterial colonies will help prevent the yeasts from re-attaching to your intestinal wall.

Studies also show that when candida yeast enzymes attack the cell wall of Candida yeasts, it begins to scramble and beef up its cell wall structure. It will beef up the cell wall with parts that are not under attack in an attempt to survive, which results in not being able to get rid of the over growth. You will probably have some relief but in order to maintain the health gains you've made, you may need to continue taking enzymes indefinitely. So it is extremely important that you take an enzyme formula that removes all parts of the biofilm and cell structure.

To keep it simple

• mannoproteins make up 55% of the biofilm and cell wall
  
• polysaccharide carbohydrates make up 25% of the structures
• lipids or fats are 15%
  
• nucleic acids are 5%.
  
• In addition, microorganisms such as bacteria and yeast use fibrinogen and fibronectin to adhere and make biofilms with the help of fibronectin binding proteins present in these microorganisms.

If you would like to get the full understanding of how these candida yeast enzymes work, it is best that you go read the "Enzymes for Yeast" page.

Reading the "Structure of Candida" would be a good idea as well.

Candida Yeast Enzyme Products Reviewed

Some of these Candida yeast enzyme formulas list the specific amounts of the individual enzymes and not milligrams. However, Dr. Samant and I are very familiar with the manufacturing process, we know how to convert these units to milligrams for a good comparison. Basically, active units per enzyme take up so much space in a capsule and we know what those measurements are. They can vary a little bit depending upon where the enzymes were sourced but they will be close to our milligram figures. We will use this information in this review to give you an accurate comparison.


Biofase Premium Enzymes

Biofase contains 1050mgs per 2 capsule (525mgs per 1 capsule) dose of these enzymes:

Fibrin Digesting Enzymes
Serratiopeptidase - 80,000 SPU
---------------------------------

Protein Digesting Enzymes
Protease SP - 100,000 HUT
---------------------------------

Fat Digesting Enzymes
Lipase - 600 FIP
---------------------------------

Carbohydrate Digesting Blend
Cellulase, Hemicellulase, Amylase, Invertase, Beta-glucanase, Glucoamylase - 128,000 active enzyme units combined - 800 MGS

In the other ingredients section all that is listed is the cellulose capsule so there are no fillers displacing enzyme space.

• All enzymes to remove biofilms and to attack the cell wall are present in this formula. They include:

• Protease to remove the mannoproteins and protein nucleus.

• Cellulase, hemicellulase, beta-glucanase, amylase, invertase, and glucoamylase to remove the polysaccharide carbohydrates, glucans and chitins.

• Lipase to remove the lipids and fats.

• Serrapeptase to remove the fibrin and fibrinogen found in the biofilm.
• 
  
• Serrapeptase also goes into the blood stream and cleans the blood of dead tissue, blood clots, plaque, cysts, fibrin and other unwanted microbes. It also helps reduce inflammation.

This is a complete formula that removes all parts of both yeast and bacterial biofilms. It also attacks every part of the yeast cell wall structure.

The 120 capsule bottle is new and on Amazon has no rating yet, the 180 capsule bottle is rated 4.5 Stars. On the D&G Industries website both sizes are rated 5 Stars.

The most critical review on Amazon says it is not for Candida, but the person says it works very well for bloating! We suspect this person actually has SIBO and not Candida over growth in the gut at all. They should have taken herbs with the enzymes to clear the bacterial infection.

In the other 3 Star review, the lady thought she was taking a probiotic, not an enzyme formula.

Biofase typically sells for $68.95 per 180 capsules which is .38 cents per capsule. The 120 capsule bottles sells for $50.95 which is .42 cents per capsule.

Check Amazon Pricing  Check D&G Industries Pricing  Check Ebay Pricing

Interfase Enzymes

Interfase contains 850mgs per 2 capsule (425mgs per 1 capsule) dose of these enzymes:

Fibrin Digesting Enzymes
Serratiopeptidase
---------------------------------

Protein Digesting Enzymes
Protease/Peptidase
---------------------------------

Fat Digesting Enzymes
None
---------------------------------

Carbohydrate Digesting Blend
Glucoamylase
Chitosanase
Cellulase
Hemicellulase
Beta-glucanase
Lysozyme

In the other ingredients section it lists ascorbyl palmitate and microcrystaline cellulose for fillers.

• The Protease/Peptidase will remove the mannoproteins.

• Glucoamylase, chitosanase, cellulase, hemicellulase, beta-glucanase will remove the polysaccharide carbohydrates, glucans and chitins.

• Serratiapeptidase removes the fibrin and fibrinogen.

• It does not contain an enzyme to remove the fats and lipids.

• Lysozyme however does attack bacteria cell walls.
  

The Amazon reviews have it rated at 4.5 Stars.

There are five 1 Star reviews. Most of them are saying Interfase did not help with their SIBO or bloating. None of these reviews say anything about taking herbs along side the enzymes.

Interfase sells for $59.99 per 120 capsules which is .499 cents per capsule.

Check Amazon Pricing 

Candifense Enzymes

Candifense contains 1,110 mgs per 2 capsules of these enzymes:

Fibrin Digesting Enzymes
None
---------------------------------

Protein Digesting Enzymes
None
---------------------------------

Fat Digesting Enzymes
None
---------------------------------

Carbohydrate Digesting Blend

Cellulase           70000 CU   - 400mgs       
Hemicellulase   40000 HCU  - 50mgs           
Xylanase              2000 XU  - 7mgs                               
Amylase            2000 SKBU - 13mgs          
Invertase              500 SU   - 5mgs         
Beta-glucanase     200 Bgu  - 35mgs     

Total active enzyme units - 112,700

Other ingredients are listed as microcrystalline cellulose and a hypromellose capsule.

510 total milligrams of enzymes, but based on possible sources of these enzymes lets say 600 to 800mgs total, the rest is microcrystalline cellulose.

• All of these enzymes will remove the polysaccharide carbohydrates, glucans and chitins.

• There aren't any enzymes to remove the proteins, fats or fibrin and fibrinogen.
  

The Amazon reviews have it rated at 4 Stars.

There are 17 - 1 Star ratings with 10 written reviews. All of them complain of severe stomach pain, diarrhea, nausea, and some people experienced vomiting.

Candifense typically sells on Amazon for 69.97 for 120 capsules, which is .58 cents per capsule.

Check Amazon Pricing

Candex Enzymes

A 2 capsule dose of Candex contains these enzymes:

Fibrin Digesting Enzymes
None
---------------------------------

Protein Digesting Enzymes
None
---------------------------------

Fat Digesting Enzymes
None
---------------------------------

Carbohydrate Digesting Blend

Cellulase           64000 CU    - 352mgs
Hemicellulase    40000 HCU  - 50mgs
Amylase             4000 SKB   - 26mgs   
Invertase            1000 SU    - 10mgs
Glycoamylase        200 AG    - 200mgs

Total active carbohydrate digesting enzymes - 109,200 units - 638mgs

Other ingredients are listed as microcrystalline cellulose and l-leucine for fillers, and a pullulan capsule.

638 total milligrams of enzymes, but based on possible sources of these enzymes lets say 800mgs total.

• All of these enzymes will remove the polysaccharide carbohydrates, glucans and chitins.

• There isn't an enzyme to remove the proteins, fats or fibrin and fibrinogen.

The Amazon reviews have it rated at 5 Stars.

There is one 3 Star rating and one 4 Star rating. They wished it also had protease in it.

Candex typically sells for $47.99 for 120 capsules on Amazon, which is .399 cents per capsule.

Check Amazon Pricing


Candidase Enzymes

A 2 capsule dose of Candidase contains these enzymes:

Fibrin Digesting Enzymes
None
---------------------------------

Fat Digesting Enzymes
None
---------------------------------

Carbohydrate Digesting Blend
Cellulase Thera-blend 60,000 CU - 350mgs
-------------------------------------

Protease Digesting Blend
Protease Thera-blend  230,000 HUT -  240mgs

Other ingredients show no fillers, just the cellulose capsule.

The conversion to milligrams is tricky because we don't know what else is in these Thera-blends. However, if there's nothing extra and the name is nothing more than a trademark, there is 590mgs of enzymes per dose. It would be safe to say possibly 700mgs or maybe 800mgs.

• The protease blend will remove the mannoproteins and proteins in the nucleus.

• The cellulase blend will remove the polysaccharide carbohydrates, glucans and chitins.

• There are no enzymes for the fats or the fibrin and fibrinogen.
  

The Amazon reviews rate Candidase at 4.5 Stars.

There are 26 - 1 Star ratings and 10 written reviews. Most complain of stomach pain or it didn't work at all.

Candidase typically sells for $53.99 per 120 capsules which is .45 cents per capsule.

Check Amazon Pricing


Serradefend Enzymes

Serradefend contains these enzyme amounts per 2 capsule:

Fibrin Digesting Enzymes
Serrapeptase 90,000 spu
Nattokinase 1400 fu
-----------------------------------------

Protein Digesting Enzymes
Protease 20,000 hut
-----------------------------------------

Fat Digesting Enzymes
None
-----------------------------------------

Carbohydrate Digesting Blend
Cellulase 10,000 cu - 54mgs
Hemicellulase 10,000 hcu - 14mgs
Chitosanase - 100mgs
Amylase 24,000 du -148mgs
Glucoamylase 30 ag - 30mgs
Beta-Glucanase 140 bgu - 4mgs

Total active carbohydrate digesting enzymes - 45,000 units - 350mgs

In the other ingredients section it lists maltodextrin and cellulose capsules.

• The protease will help remove the mannoproteins.

• Glucoamylase, chitosanase, cellulase, hemicellulase, amylase, beta-glucanase will remove the polysaccharide carbohydrates, glucans and chitins.

• Serrapeptase and nattokinase will remove the fibrin and fibrinogen.

• It does not contain an enzyme for the fats and lipids.
  

The Amazon reviews rate it at 4.4 and the Balanceone website shows eight 5 Star ratings. None of the people that left low ratings entered any comments.

SerraDefend sells for $28.97 per 60 capsules which is .48 cents per capsule.  

Check Amazon Pricing

Conclussion

Based on the contents and amounts of each candida yeast enzyme formula, Biofase is the only enzyme formula that contains all the enzymes needed to remove all parts of the biofilm and yeast cell wall. It is also the strongest formula on the market at the best price.

There are enzyme medical studies with testimonials from real people on this webpage about Biofase, and more testimonials here if you care to read them.

Hi Dan,

Please post this testimonial on your website.

I have been suffering with systemic candidiasis for around 7 years and anyone who has been dealing with the same problem knows it is quite different than a yeast infection and extremely hard to get rid of. For years I have been taking Candex and it has helped but it has not eliminated my candida. Two weeks ago I decided to try Biofase for yeast and I have noticed a huge difference, it is head and shoulders above Candex. I would compare Candex to a handgun and Biofase to a bazooka and believe me when combating candida you want the bazooka as this disease is extremely ruthless. From here on out I will be ordering Biofase. Thank you Dan for all your research that has gone into making this product!

Dave

Dr. Vibhuti Rana, PhD says...

The above information regarding the enzyme formulations for different yeast biofilm-digesting enzymes is correct. The enzyme compositions for the products compared above are quite similar. Hemicellulase and cellulase have a high anti-biofilm activity and work well for a number of fungal and bacterial species, like Candida species, P. aeruginosa and K. pneumoniae. Likewise, chitosanase which is found in cellulase, works in the same manner for a number of Gram positive and Gram-negative species of biofilm producers (1, 2). Therefore, selecting the formula which gives you maximum benefit at an optimum price would be the best step towards getting rid of Candida biofilm species’ biofilms. Moreover, when complemented with the use of antifungal drugs like amphotericin B, azole-class drugs, echinocandins, etc. will completely eradicate the infections.

1. Muslim SN, Al-Kadmy IMS, Hussein NH, Mohammed Ali AN, Taha BM, Aziz SN, Kheraif AAA, Divakar DD, Ramakrishnaiah R. Chitosanase purified from bacterial isolate Bacillus licheniformis of ruined vegetables displays broad spectrum biofilm inhibition. Microb Pathog. 2016 Nov;100:257-262. doi: 10.1016/j.micpath.2016.10.001. Epub 2016 Oct 8. PMID: 27725283.https://pubmed.ncbi.nlm.nih.gov/27725283/#
2. Asli A, Brouillette E, Ster C, Ghinet MG, Brzezinski R, Lacasse P, Jacques M, Malouin F. Antibiofilm and antibacterial effects of specific chitosan molecules on Staphylococcus aureus isolates associated with bovine mastitis. PLoS One. 2017 May 9;12(5):e0176988. doi: 10.1371/journal.pone.0176988. PMID: 28486482; PMCID: PMC5423679. https://pubmed.ncbi.nlm.nih.gov/28486482

How Candida Yeast Enzymes Work

Yeast and Candida have a very hard time adapting to these enzymes for yeast just like they do to bacteria but they do indeed attempt to do so by scrambling their cell wall structure. They will beef up the components of the cell wall not under attack in order to survive, that's why it is so important to take a complete formula that attacks all the pieces of the cell wall.

We also suggest herbs that work for yeasts be taken as well or at least a probiotic that contains bacteria that have been found to clear yeasts.

The enzymes will boost the effects of prescription medications like Diflucan because Diflucan cannot remove the biofilm. Diflucan can cause Candida yeasts to shape shift and become a resistant strain like Candida glabrata and Candida krusei. Both of these yeasts are highly resistant to Diflucan and are very hard to get rid of. But by stripping the biofilm with enzymes first, the success rate of using Diflucan increases significantly the first time, which helps prevent shape shifting and relapses.

Dr. Vibhuti Rana, PhD says...

I agree with the mechanisms behind which these enzymes work. Fungal biofilms comprise of polysaccharides, networking proteins of the extracellular matrix, and lipids or fatty acids. It is formed by a number of Candida species such as Candida albicans, C. krusei, C. guilliermondii, C. lusitaniae, and C. tropicalis. For any formula to work successfully, the enzymes need to work at all the levels of microbial biofilm construction-carbohydrate, proteins, and fats. Once the biofilm is broken down, the Candida yeast becomes susceptible to elimination by the immune system of the host, and flourishes the good bacteria in the gut (1, 2).

Serrapeptase is a proteolytic enzyme that has a significant role in breakdown of the networking proteins due to their fibrinolytic (fibrinogen digesting) properties. It has wide applications in reducing inflammation and infections where microbial films play a major role, e.g transplant-associated infections (3). Nattokinase, which destroys amyloid in biofilms, and serrapeptase, which digests fibronectin, are key enzyme molecules which facilitate the access of antifungal drugs at the site of infection (4).

As mentioned above, once the biofilm, which acts like the safe haven to hazardous infections fungal and bacterial species, is stripped off, the antifungal drugs or herbs manifest their action and give effective results.

1. https://link.springer.com/article/10.1007/s00253-020-10595-y
2. Bizerra FC, Nakamura CV, de Poersch C, et al. Characteristics of biofilm formation by Candida tropicalis and antifungal resistance. FEMS Yeast Res. 2008;8(3):442-450. doi:10.1111/j.1567-1364.2007.00347.x. https://pubmed.ncbi.nlm.nih.gov/18248413/
3. https://journals.lww.com/jbjsjournal/Abstract/2006/06000/The_Effect_of_Proteolytic_Enzyme_Serratiopeptidase.6.aspx4
4. https://blog.designsforhealth.com/biofilms-and-resistance

Candida Yeast Enzymes vs Digestive Enzymes

I get asked quite often if digestive enzymes would work as well as a yeast eating enzyme because they are cheaper, and generally contain the very same enzymes as an enzyme for yeast, so here's a comparison.

The label on the right is from a 120 capsule bottle of Candex. The enzyme amounts are per two capsules so lets narrow this down to one capsule.

Cellulase 32,000 cu
Hemicellulase 20,000 hcu
Amylase 2000 skb
Invertase 500 su
Glucoamylase 100 ag

Notice the large amounts of cellulase and hemicellulase. All yeast eating enzymes will contain these in large amounts because of the glucan, chitin and cellulistic plant matter in the biofilm and cell wall, (membrane), of Candida yeast.

The next label is from a Doctors Best Digestive Enzyme formula and ingredients listed are per one capsule. Although this formula is heavy on protein digesting enzymes and has a broad range of sugar digesting enzymes, the glucan, chitin and cellulistic plant matter digestive enzymes are insufficient. The amounts are:

Cellulase is 3250 cu
Hemicellulase is 750 hcu

Candex has over 10 times the amount of cellulase and 26 times the amount of hemicellulase. You will find all enzymes for yeast contain these high amounts because it is required to have any success at removing the biofilm and clearing the infection.

Are Candida Yeast Enzymes Safe to Take?

Yes. There are no known toxicity issues with any of these enzymes for yeast.

As a matter of fact, in the book, Enzymes: The Fountain of Life by K. Miehlke, R. M. Williams, D. A. Lopez; they reference studies done on rats and guinea pigs and observed no ill effects at daily doses that are equivalent to 250 capsules a day for a 134 pound person.

In another study, rats were fed the equivalent of 2500 capsules a day daily for a short period and the rats only seemed a little fatigued. Research has also looked at cell changes and mutations. They found no negative affects at all.

They have been given GRAS status by the FDA.

What are the possible side effects of enzymes for Candida yeast?

In our experience, in highly toxic individuals with high levels of yeasts or bad bacteria, it is entirely possible to have a cleansing reaction.

These people may experience nausea, a “burning sensation” in the stomach, or abdominal cramping. This is because the enzymes may aggravate pre-existing problems in the GI tract, basically they are working. If this occurs, I suggest using one half of a capsule, twice daily, emptied into eight ounces of warm water, and building up from there. To avoid this problem to start with take one capsule the first three days, two capsules day four through six, and so on, until you reach the recommended daily dose.

Many people that have the stomach pains have found that if they stop taking them altogether for a couple of days, then start back up at a lower dose, they don't have anymore problems.

Another method that works well is to take a probiotic that is designed to kill yeast, such as Profase, for a week or two prior to taking the enzymes.

Enzymes that do attack all the components of the cell wall can also cause the yeast to release spores in an effort to survive, which makes the infection worse. If this happens to you the best thing to do is raise the dose, or add herbs and probiotics to help nock it down as quick as possible. Quite frankly, the best way to treat these infections is with all three; enzymes, herbs and probiotics.

How to Take Candida Yeast Enzymes

The Best way is to incorporate them into a this 3-Step Treatment Plan here.

Otherwise...

Many times when using enzymes for yeast, a change in diet is not needed if the yeast infection is mild. However, it makes sense to not feed the yeast when you are trying to get rid of it. Why give it something to fight back with? It just doesn't make sense does it?

Generally, I would follow the directions on the label. But it is important to take these enzymes at least one hour or more before breakfast and at bedtime. You don't want to take them with food or any supplements that contain fiber because the enzymes will digest those and not do what you want them to do.

These enzymes for yeast infections are safe for children and the recommended dose is one-half capsule, twice daily, for each 40 pounds of body weight. However, I can't speak for the other enzymes above, but I have one year olds taking one Biofase with one Profase twice a day with very good results. For ages 14 and up, adult recommendations may be followed.

It is best to take them away from food, one hour or more before breakfast and at bedtime.

Medical Review by Dr. Atmika Paudel, PhD

This is not an endorsement of the products and I do not want to comment upon the comparisons of the products mentioned in the article, but to the best of my knowledge the active constituents that the yeast enzyme contains such as cellulase, hemi-cellulase, invertase, protease, lipase, and amylase fall under the Generally Recognized As Safe (GRAS) category of the U.S. Food and Drug Administration (FDA), when they are derived from the source mentioned by FDA.

Cellulase is known to disrupt the biofilms of microorganisms, which are generally difficult to penetrate through by antibiotics. Although yeast cell wall contains chitin instead of cellulose in plant cell, cellulase, hemicellulase, lysozyme, pectinase, and alpha amylase are non-specific enzymes and have been used for breaking down chitin (1).

Fibrinogen and fibronectin are components of human body that have important functions in wound healing and blood clotting. Microorganisms such as bacteria and yeast use fibrinogen and fibronectin to adhere and make biofilms with the help of fibronectin binding proteins present in these microorganisms. Therefore, appropriate caution should be taken when taking products containing enzymes whose long-term safety are not well-known. Another important factor to be cautious is taking other medications together with the enzymes- for example- serratiopeptidase and nattokinase may interact with medications used for blood thinning purposes.

1. Advances in Food and Nutrition Research. Volume 65, 2012, Pages 321-336 Chapter 21 - Chitooligosaccharides as Potential Nutraceuticals: Production and Bioactivities

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