FTC Disclaimer: I do receive financial compensation for some of the products I recommend and personally sell.

Do Enzymes For Yeast Infection and Candida Really Work??

Enzymes for yeast eat the cell wall of candida and other yeasts because the cell wall is composed of fiber and glycoproteins. Many times the patient will not experience any die-off reaction at all, especially when using an enzyme that contains protease, which is a huge bonus.

yeast cell wall structure

Candida yeast has a cell wall composed of mannoprotein-1, glucan, chitin-glucan, mannoprotein-2 and plasma membrane.

A mannoprotein is a complex carbohydrate-modified protein used by yeasts to anchor the proteins to the cell wall glucans.

Glucans are a polysaccharide fiber, that are found in the cell walls of bacteria, fungi, algae, lichens and plants such as oats and barley.

Chitins are long-chain polymer of N-acetylglucosamine, which is a derivative of glucose. It is a primary component of fungal cell walls and the exoskeletons of arthropods. It is very similar to the polysaccharide cellulose - the basic fiber component of plant cell walls.

The plasma membrane is a fatty lipid and protein layer and the nucleus of the yeast cell is also made of protein.

Knowing that the cell wall of candida yeast is made up of proteins with carbohydrate rich fibers including a protein and lipid nucleus, a properly designed enzyme formula should contain the necessary enzymes to digest all of these parts.

The enzymes for yeast formula should also contain the enzymes necessary to eat through the biofilm yeast builds around itself as a means of protection. Biofilms are used by pathogenic yeasts, bacteria and viruses as a way to hide from the hosts immune system. At the same time the pathogen will release spores or cells in an attempt to spread throughout the body. Upon release of the spores the immune system mounts a defense, which causes inflammation and can make you feel sick.

The biofilm will form in the section of the picture marked F. More on biofilms here.

Inferior Yeast Eating Enzymes

There are many enzymes for yeast formulas on the market today but I only want to take a look at the three most popular. They are:

  • Candex
  • Candizyme
  • Candidase
  • There are others, but most are slightly different variations of the above products.

Candex contains cellulase, hemicellulase, amylase, invertase and glucoamylase. It does not contain any protease to eat the mannoproteins and nucleus or serrapeptase to eat the fibrinogen in the biofilm.

Because Candex does not contain a fibrinogen or protein eating enzyme and is therefore incomplete and would not be my first choice.

Candidase contains a Cellulase Thera-blend to eat the cell wall and a Protease Thera-blend™ to eat the protein components. The amount of enzymes per dose are very high, especially the protease, which has been said to minimize any die-off reactions. However, this formula is incomplete, there are no enzymes to eat the polysaccharides or fibrinogen in the biofilm.

Candizyme contains cellulase and hemicelluse that eats the biofilm and cell wall.  Protease to eat the mannoproteins and nucleus and the starch eating enzymes lysozyme, amylase, lactase, malt diastase and glucoamylase to help with the polysaccharides in the biofilm. This is a pretty good formula for breaking through the biofilm and eating the cell wall of candida yeast. However, Candizyme lacks an enzyme that eats the fibrinogen in the biofilm, so it is also incomplete.

If I was going to use any of the above three enzyme formulas, I would take it with SerraEnzyme so you have an enzyme that will eat the fibrinogen in the biofilm.  

If you added Microfase and the Profase probiotic you would have a pretty good candida yeast killing combination. I would take one or two capsules of Profase every time I took any of the enzymes above and two to four Microfase 30 minutes later.

Superior Enzymes for Yeast

Biofase for yeast is very similar to the four enzyme formulas below. It contains cellulase and hemicellase to eat the glucan and chitin component in the biofilm and yeast cell. Glucoamylase, amylase and invertase to eat the polysaccharides in the biofilm and cell wall. Protease to eat the polypeptides of the biofilm, mannoproteins and nucleus of the yeast cell. Biofase also includes a serrapeptase enzyme that eats the fibrinogen of the biofilm making it a complete yeast eating enzyme.

Serrapeptase also goes into the blood stream and cleans the blood of dead tissue, blood clots, plaque, cysts, fibrin and other unwanted microbes. It also helps reduce inflammation.

This study done by Loiselle M, Anderson KW at the Department of Chemical and Materials Engineering, University of Kentucky proves that these enzymes work on the biofilms that protect bad bacteria, yeast and viruses as well. There are more links to studies on the Biofase and biofilm page above.

Biofase works extremely well when combined with Microfase, which is an herbal formula containing ingredients proven to kill yeasts; and Profase, a probiotic that is designed to kill yeast and raise immune function. The enzymes eat the biofilm and the yeast cell while also exposing it to the yeast killing herbs in Microfase. Profase provides further cleansing action and the good bacteria clean up the waste and prevents reattachment of the candida yeast to the intestinal wall. Profase also boosts good bacterial levels, which is more than likely the cause of the infection to start with.

Yeast and candida have a very hard time adapting to these enzymes for yeast just like they do to bacteria. They will boost the effects of prescription medications like Diflucan because Diflucan cannot remove the biofilm. They have no risk to your health and do not cause the candida to mutate, which Diflucan has been proven to do. Diflucan can cause yeast and candida to shape shift and become a resistant strain like candida glabrata and candida krusei. Both of these yeasts are highly resistant to Diflucan and are very hard to get rid of.

Enzymes for Yeast Price Comparison

Candex costs about $47.00 for 120 capsules, add SerraEnzyme for $25.00 for a total of $72.00.

Candidase runs about $39.00 for 84 capsules plus the $25.00 for SerraEnzyme equals $64.00.

Candizyme costs about $35.00 for 90 capsules plus the $25.00 for SerraEnzyme costs you $60.00.

A Biofase 90 capsule bottle is only $39.95. A bargain when you consider you don't have to buy SerraEnzyme because serrapeptase, along with all the other enzymes required to eat the cell wall and biofilm, are in the formula.

Biofase is also offered in a 180 capsule bottle for $67.95 which lowers your expense to $33.97 per 90 capsules if you choose this bottle size.

Yeast Eating Enzymes vs Digestive Enzymes

I get asked quite often if digestive enzymes would work as well as a yeast eating enzyme because they are cheaper, and generally contain the very same enzymes as an enzyme for yeast, so here's a comparison.

candex label

The label on the right is from a 120 capsule bottle of Candex. The enzyme amounts are per two capsules so lets narrow this down to one capsule.

Cellulase 32,000 cu
Hemicellulase 20,000 hcu
Amylase 2000 skb
Invertase 500 su
Glucoamylase 100 ag

Notice the large amounts of cellulase and hemicellulase. All yeast eating enzymes will contain these in large amounts because of the glucan, chitin and cellulistic plant matter in the biofilm and cell wall, (membrane), of candida yeast.

digestive enzyme label

The next label is from a Doctors Best Digestive Enzyme formula and ingredients listed are per one capsule. Although this formula is heavy on protein digesting enzymes and has a broad range of sugar digesting enzymes, the glucan, chitin and cellulistic plant matter digestive enzymes are insufficient. The amounts are:

Cellulase is 3250 cu
Hemicellulase is 750 hcu

Candex has over 10 times the amount of cellulase and 26 times the amount of hemicellulase. You will find all enzymes for yeast contain these high amounts because it is required to have any success at clearing yeast infections.

Biofase Verses It's Closest Competitor

In my opinion, Biofase's closest competitor is Klaire Labs Interfase so lets do an honest comparison.

Comparing the label of Interfase to Biofase we see very similar enzyme profiles with Interfase having Beta-Glucanase and Chitosanase where Biofase does not.

However, we have tested the Cellulase and Hemi-cellulase enzymes in Biofase and they do show Beta-Glucanase and Chitosanase activity.

Chitosanase digests the very same thing as Cellulase and Hemicellulase so it really is not needed. As a matter of fact, chitin and cellulose are both made from glucose monomers, or monosaccharides, but instead of a hydroxyl group, the glucose molecules in chitin have an amyl group attached that consists of carbon and nitrogen. Cellulase and Hemicellulase digest it very effectively.

We also see that each capsule is 425mgs.

If we click on the link above for Interfase we see that it currently sells for $52.95 on Amazon for 120 - 425mg capsules, total mgs per bottle is 51000. Per capsule cost is .441 cents.

Looking at the label for Biofase we see each capsule contains 525mgs so Biofase per capsule is stronger than Interfase. Total milligrams per 120 capsules is 63000.

Biofase comes in both a 90 capsule bottle and a 180 capsule bottle with the 180's costing $67.95. That's .377 cents per capsule so a 120 capsule bottle, if there was such a thing, would cost $45.24. And... you are getting more milligrams and a stronger formula.

D&G Industries also offers a 10% off Loyalty program for all orders after the first if you leave a review on the store website. That makes that $45.24 per 120 capsules turn into $40.71 ;)

You may have noticed that both Biofase and Interfase are Proprietary blends and list their enzymes in milligrams verses the specific enzyme activity of other brands. Proprietary refers to a patent, or ownership. Applying this to Biofase and Interfase, it means each company owns the rights to their specific blend of enzymes, making these products different from similarly marketed systemic enzyme supplements. This is not done to hide anything but does help to prevent foreign copycats. It's also meant to hopefully make the decision of choosing a product easier by simplifying what the product is and what it is intended to do.

In all honesty, listing enzyme activity levels for any blended enzyme formula is meaningless. No one can tell you what 32,000cu of cellulase is going to do in the body, or what 80,000spu's of serrapepetase is going to do either. In single enzyme formulas it can help to determine what's a better buy. But in blended formulas, all that matters is if it works or not. Biofase is formulated to work, which is all that matters, this is what Dave has to say:

Hi Dan,

Please post this testimonial on your website.

I have been suffering with systemic candidiasis for around 7 years and anyone who has been dealing with the same problem knows it is quite different than a yeast infection and extremely hard to get rid of. For years I have been taking Candex and it has helped but it has not eliminated my candida. Two weeks ago I decided to try Biofase for yeast and I have noticed a huge difference, it is head and shoulders above Candex. I would compare Candex to a handgun and Biofase to a bazooka and believe me when combating candida you want the bazooka as this disease is extremely ruthless. From here on out I will be ordering Biofase. Thank you Dan for all your research that has gone into making this product!


There are enzyme medical studies with testimonials from real people on this webpage about Biofase, and more testimonials here and here if you care to read them. There are also testimonials on this store website along with a Star rating.

How to Take Yeast Eating Enzymes

Many times when using enzymes for yeast, a change in diet is not needed if the yeast infection is mild. However, it makes sense to not feed the yeast when you are trying to get rid of it. Why give it something to fight back with? It just doesn't make sense does it?

While die-off reactions usually do not occur with these enzymes for yeast infection, some people may experience nausea, a “burning sensation” in the stomach, or abdominal cramping. This is because the enzymes may aggravate pre-existing problems in the GI tract, basically they are working. If this occurs, I suggest using one half of a capsule, twice daily, emptied into eight ounces of warm water, and building up from there. To avoid this problem to start with take one capsule the first three days, two capsules day four through six, and so on, until you reach the recommended daily dose.

Many people that have the stomach pains have found that if they stop taking them altogether for a couple of days, then start back up at a lower dose, they don't have anymore problems.

These enzymes for yeast infection are safe for children and the recommended dose is one-half capsule, twice daily, for each 40 pounds of body weight. However, I can't speak for the other enzymes above, but I have one year olds taking one Biofase with one Profase twice a day with very good results. For ages 14 and up, adult recommendations may be followed.

It is best to take them away from food, one hour or more before breakfast and at bedtime.

Yeast Infection Advisor Home

If you have any questions about these enzymes for yeast infection please feel free to contact me from the contact page of this website.

Privacy Policy  Copyright Policy  Disclosure Policy

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information contained herein are not intended to diagnose, treat, cure, or prevent any diseases or medical problems. It is not intended to replace your doctor's recommendations.

Copyright © 2003 - 2018. All Rights Reserved under USC Title 17.
Do not copy content from the page or this website without my expressed written consent. To do so is Plagiarism, Not Fair Use, is illegal, and a violation of the The Digital Millennium Copyright Act of 1998.