Dr. Atmika Paudel PhD says... I am not endorsing any of the products, but the facts about the contents of Syntol, their benefits and possible side effects are medically correct.
I personally believe Syntol for yeast infections is superior to Threelac, Fivelac, Probio5, Candex, YST Management and almost all other specialty probiotic enzyme formulas for yeast except for Biofase and below are the reasons why. I'll take a look at these formulas briefly and their contents. You can also read the pages describing each product for further information.
First off, let's take a look at the contents of Threelac. Threelac contains 200 Million CFU's of three different strains of bacteria that are said to eat yeast along with fiber, lemon juice powder for flavor, and refined yeast powder that is said to keep the bacteria alive. That's it, that is all it contains.
Fivelac contains the same bacteria as Threelac but in a much higher dose, 1.5 billion; plus they added Bifidobacterium longum and Lactobacillus acidophilus for a total bacterial count that is a little over 2 billion. It also contains the yeast powder, Fructooligosaccharides (FOS), fiber, lemon juice powder, silica, canola oil and the artificial sweetener erythritol.
Probio5 contains 200mgs of the enzymes protease, peptizyme, cellulase and chitosinase that are designed to eat yeast like YST Management or Candex; and 100mgs of the bacteria Lactobacillus sporogenes, L. acidophilus, L. plantarium, Bifidobacterium longum and Saccharomyces boulardi. 100mgs of bacteria is about 1 billion colony forming units. It also has a little vitamin C, grapeseed extract and vitamin B6.
Candex and YST Management contain an incomplete profile of enzymes so they do not breakdown the biofilm that yeast builds over itself as a means of protection.
One dose of Syntol for yeast infections contains 13.6 billion cfu's of beneficial bacteria, far more than any of these others. The bacterial species are L. acidophilus, L. lactis, L. plantarium, L. helveticus, Bifidobacterium bifidum, and Bacillus subtilis. Many of them produce hydrogen peroxides that kill bad bacteria and fungi.
Bacillus subtilis was discovered in 1835 and was named Vibrio subtilis by Christian Gottfried Ehrenberg, and renamed Bacillus subtilis by Ferdinand Cohn in 1872.
B. subtilis was used in the 1940' and
50's because it was found to stimulate broad spectrum immune
activity. It was also used for treating Rotavirus and Shigella.
You might run across other websites claiming that B. subtilis is used to make antibiotics and therefore kills all your good bacteria, this is partially true.
In 1945, John T. Goorley isolated a strain of Bacillus subtilis
from a girl named Tracy who had a compound fracture in her leg. The B. subtilis was helping this girl fight off a Staph. infection because of
its antibiotic ability. In 1948 they created an antibiotic called
Bacitracin from this B. subtilis strain that they named Tracy 1.
Bacitracin is still in use today in the form of an antibiotic cream,
because it does not work in the intestine, to treat staph infections on the skin.
Syntol for yeast infections does not contain the Tracy 1 strain of B. subtilis!
Furthermore, all good bacteria, such as L. acidophilus, have antibiotic properties because they make hydrogen peroxides. It does not hurt the good bacteria that make it; that would be suicide and it makes no sense that they would do this to themselves... does it?
Micro-biologist J. Harmann's research showed Bacillus subtilis was able to stimulate IgA, IgM and IgG antibodies therefor boosting the function of the immune system. This is important because IgA especially is what defends the mucosal linings of the body from infections like Candida. The other two work on long term Candida infections that have become systemic. These antibodies also defend the body from bad bacteria and viruses.
Most importantly, a 2018 study that was published in Microbiological Research Journal, found that Bacillus subtilis inhibited biofilm formation of Candida albicans. It also inhibited it from shifting from spore form to hyphael form, and inhibited its enzyme activity. It caused a reduction in egosterol content which resulted in down regulating its drug resistance abilities.
Bacillus subtilis products are still in use today in Europe and Israel by the medical community.
The bacteria in Syntol for yeast infections have been forced into a spore form. Sporulated bacteria, or a bacteria that has been forced into a spore form, have been found to survive the stomach acids intact and make it to the intestines where they need to be. Once in the intestine, the spores attach to the intestinal wall and germinate and become living. It is a very effective delivery system designed to get these bacteria to the intestine where they are the most beneficial.
Sporulated bacteria also do not have to be refrigerated because technically they are not alive until they germinate in your intestine. This also means they will not spoil and grow molds while in storage.
Syntol also contains Saccharomyces boulardii, which is a substrain of Saccharomyces cerevisaie bakers' yeast. Saccharomyces boulardii has been used to treat acute diarrhea caused by IBS, IBD, C. Difficile, Travelers diarrhea, HIV/AIDS related diarrhea, and antibiotic associated diarrhea.
One serving, 4 capsules of Syntol for yeast infections also contains about 1240mgs of the yeast eating enzymes cellulase, hemicellulase, protease, amylase, glucoamylase and serrapeptase. Some of these enzymes are found in other products such as Candex, Candizyme and YST Management and in clinical studies have been found to eat the cell wall of yeast. The enzymes are enteric coated as well so they do get into the intestine. Vitamin C and a little oligosaccharide, a type of FOS that does not feed bad bacteria, are also in the formula.
Serrapeptase however is not found in Candex, Candizyme or YST Management and
neither one of those enzymes products contain any good bacteria.
Serrapeptase is a systemic enzyme that helps reduce swelling, fluid
retention and reduces inflammation caused by yeast or other reasons. It
also reduces pain and is often used in Europe in place of ibuprofen and
other NSAIDS. It also eats the fibrinogen, which candida and bacteria use to adhere and make biofilms. None of the other yeast eating enzymes on the market do this except for Biofase. More on biofilms here.
A lot of companies will enteric coat their bacterial products so that they can survive the stomach acids intact and make it to the intestines alive. They typically use Pthalates, which are essentially plastic chemicals. Arthur Andrew Medical utilizes acid resistant Acid Armor® capsules. These capsules are made of dense vegetable cellulose with a more precise micro-threaded locking mechanism, in order to prevent premature leakage of the capsule's contents. When syntol for yeast infections is taken on an empty stomach with water, you can rest assured the contents do reach the intestines intact.
The results of a recent Syntol Clinical Study that was published in Healthy Living Magazine confirms it. Dr. Stefan Bajon conducted the study and he found that Syntol AMD was able to clear Candida with very little if any die-off reaction. He claims, Syntol even removed Candida yeast from the blood. Read the study, it's short and written in layman's terms so anyone can understand it.
Note: The blood analysis test was used using a blood sample on a slide, then placed under a microscope. This is not a valid test, it is subjective to the person viewing the sample. Yeast in the blood is extremely rare although it is on the rise in patients with life threatening diseases such as cancer. Hyphae producing strains of yeast in the blood usually result in death.
Dr. Vibhuti Rana, PhD says...
While I cannot comment of the differential efficacy of Syntol and other products described in this article, I agree with the description of the bacterial/fungal strain properties that are a part of the composition.
Syntol comprises of Lactobacillus acidophilus, L. rhanmnosus, L. lactis, L. plantarium, L. helveticus, Bifidobacterium bifidum, S. boulardii and B. subtilis. These ingredients have great probiotic properties which help to maintain a healthy gut balance by downplaying the yeast and bad bacterial pathogens. These microbial species also provide host benefits like modulation of the immune system components, anti-inflammatory action, better intestinal health or functioning, killing or inhibiting the growth of pathogens, and improvement in conditions such as traveler’s diarrhea (1). Not only do they maintain optimum pH in the human gut, they (specifically B. subtilis) also target the biofilm formation by the Candida yeast species (2). If the fungal biofilms are weakened, the pathogenic cells become more available and vulnerable to anti fungal treatment.
The ingredients of vegan-friendly Syntol also have the property of alleviating the leaky gut syndrome, which happens when Candida infections are significantly high in the gut and rhizoid formation takes place, which could initiate a pro inflammatory auto immune response (3). The serratiopeptidase metalloprotease enzyme or serrapeptase belongs to trypsin family and has anti-infective properties. It is a potent anti-inflammatory agent used for treatment of various disorders like bronchitis, arthritis, sinusitis, carpal-tunnel syndrome, etc (4). These days, polymer-based capsules are being used with enteric coating to effectively deliver the probiotic strains/compositions in the gut. These provide the patients with cheaper alternative since freeze thawing may result in loss of vigor of the products (5).
Bacillus subtillis is known to cause disease in severely
immuno-compromised patients. However, this documented case involved a 73
year old man that had leukemia and chemotherapy so he was severely
It has however been given GRAS status by the EPA.
However, a study in 2009 determined that Bacillus subtillis is definitely part of the human intestinal flora, so I would not worry too much about becoming infected by it unless you are a cancer patient on chemotherapy.(2)
There have been many cases of people getting infected with S. boulardii, which is simply the commercial name for Saccharomyces cerevisiae(3) and 40% of all cases reported since 1990 were because of probiotic use.(4) There is additional information about Saccharomyces cerevisiae on this webpage.
Voriconazole has been used successfully to treat sepsis due to subtype S. boulardii when fluconazole fails. Herbrecht and Nivoix have suggested that S. boulardii should not be given to patients of fragile health and patients with a central venous catheter.(5)
Dr. Vibhuti Rana, PhD says...
While the components of Syntol are generally beneficial, it is wise to exercise caution for some categories of patients. Yeasts are naturally resistant to antibacterial antibiotics, making them better probiotics than bacterial strains. While many studies report S. boulardii to be well tolerated and safe, some reports discuss their side effects too. In an Indian study, two premature neonates and five adults admitted in the intensive care units showed cases of S. cerevisiae associated fungemia upon use of S. boulardii probiotics. (1). Cases of development of fungemia have also been reported after probiotic treatment containing S. boulardii when the pediatric patient was admitted to ICU (2).
Since these are probiotic spores, they germinate once they reach at the target site in the gut. Though the constituent strains are not genetically engineered, one must be careful while using these spore germination technology products since there are not adequate studies to support their efficacy in different patient groups/populations (3). It is also best to consult your doctor if you are already on antibiotics or other metabolism-altering medication.
The article talks about a particular product and compares it with other similar products and discusses why the product is superior to other products and gives the reason based on the contents of the product.
It is claimed to contain Lactobacillus acidophilus, L. lactis, L. plantarum, L. helveticus, Bifidobacterium bifidum, Saccharomyces boulardii and Bacillus subtilis. It also claims to contain enzymes such as cellulase, hemicellulase, protease, amylase, glucoamylase and serratiopeptidase. My understanding is that the bacteria, yeast (S. boulardii), and the enzymes are separately enteric coated inside a capsule of the product which are released in the intestine, this should be clearly mentioned and emphasized in the article because if not, mixing the enzymes that damage bacterial and yeast cells with bacteria and yeast does not make sense.
A study showed that when Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 were consumed, anxiolytic-like activity in rats and beneficial psychological effects in healthy human volunteers were observed. (1)
In case of Bacillus subtilis, nonpathogenic strains should be used. There are some nonpathogenic strains which are widely available and have been safely used in a variety of food applications, for example fermented soy bean, in the form of Natto, which is commonly consumed in Japan.
I have commented about the enzymes in my commentary about Biofase here. So, I will not be repeating them here. Similarly, I have commented about Saccharomyces boulardii in this page, about Lactobacillus acidophilus, L. plantarum, Bifidobacterium bifidum in this page, and L. lactis in this page.
1. Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., . . . Cazaubiel, J. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, 105(5), 755-764. doi:10.1017/S0007114510004319
Do you have any questions about Syntol or yeast infections in general? Ask your question here or contact us using the contact page of this website. It is also always a good idea to talk to your doctor as well.
I have been using Biofase enzymes for a couple of months now with considerable success. For the past 14 months I have been on a near-paleo and sugar-free diet and taking Syntol and the CP-1, along with various antifungals. This combination of strategies based on your recommended protocols allowed me to live pretty much symptom-free until a period of high stress and a little too much relaxing of my diet led to a return of some candida symptoms last fall.
Shortly after starting on the Biofase this winter, I experienced a die-off--the first die-off in a year. Ever since then, I have observed that the Biofase seemed to return my candida to lower levels more quickly than I would have expected the Syntol to be able to do. I have already recommended Biofase to two friends who have been dealing with candida-related medical problems and I will continue to use it myself on my quest to wipe out the candida once and for all. I really appreciate your quest to find the most effective ways to kill off candida. This one was a success. Keep up the good work.
I was always struggling with yeast infections. Lately however, I have reached a point where I was unable to manage through conventional methods (prescription and over the counter anti fungals) and it's sent me on a quest to heal myself naturally. After several months of trial and error and a lot of research, I've found a combination that has boosted my ability to prevent infections and Biofase is a major component of this treatment. I take 3 Syntol, 3 Biofase and 1 Saccharomyces Boulardi in the morning and 3 Syntol and 3 Biofase at night. It took some time to figure out what my dosage needs would be for the Biofase but once I got up to 3 two times a day things clicked.
I'm very grateful.
1. Oggioni MR, Pozzi G, Valensin PE, Galieni P, Bigazzi C (January 1998). "Recurrent septicemia in an immunocompromised patient due to probiotic strains of Bacillus subtilis". J. Clin. Microbiol. 36 (1): 325–6.
2. Hong, Huynh A.; Khaneja, Reena; Tam, Nguyen M.K.; Cazzato, Alessia; Tan, Sisareuth; Urdaci, Maria; Brisson, Alain; Gasbarrini, Antonio; Barnes, Ian; Cutting, Simon M. (2009). "Bacillus subtilis isolated from the human gastrointestinal tract". Research in Microbiology 160 (2): 134–43.
3. Front Microbiol. 2015; 6: 1522. Published online 2016 Jan 8. Opportunistic Strains of Saccharomyces cerevisiae: A Potential Risk Sold in Food Products https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705302/
4. Herbrecht R, Nivoix Y. Saccharomyces cerevisiae fungemia: an adverse effect of saccharomyces boulardii probiotic adminstration. Clin Infect Dis 40:1635-1637, 2005
5. Invasive Saccharomyces infection: a comprehensive review. Clin Infect Dis 41:1559-1568, 2005.
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