What kind of anti yeast drug can penetrate the atherosclerotic plaque?

by Tony Lichaa MD
(Lebanon )

I am Dr. Tony Lichaa, a cardiologist. I have treated many patients with unstable angina with the anti yeast drug griseofulvin and registered a surprising result, but some patients do not tolerate it well. Is there any other drug that can penetrate the plaque? Thank you

Comments for What kind of anti yeast drug can penetrate the atherosclerotic plaque?

Average Rating

Click here to add your own comments

May 02, 2022
Rating

by: Dan

Griseofulvin is FDA approved to treat Tinea capitis in the US. Tinea capitis typically affects the scalp and may result in bald patches, dry areas in the scalp, or redness. It is the primary cause of ringworm. Griseofulvin penetrates the cell wall and membrane structure and targets the nucleus of the fungal cell. The only other medication that targets the nucleus, that I know of, is 5-fluorocytosine (5FC).

There are other modes of treatment that have been effective for Tinea capitis that might provide the desired effect. These drugs are terbinafine, itraconazole, and fluconazole; these medications target the membrane responsible for egosterol synthesis which is located just above the nucleus of the fungal cell. Ketoconazole, voriconazole, and posaconazole also target the membrane.

I hope you find the correlation helpful.

Oct 23, 2025
Rating

My Experience
by: Maria H

Sorry in advance my typos. I write from my cell with bad eyes lately.

I struggled for 3 years with a under diagnosed infection that was listed as contact dermatitis and insurance would not approve testing the source or type of infection. I was put on chemo drugs to mask the symptoms while it spread throughout my body and blood tests, skin rashes, stomach disorders, hair loss and several misc symptoms continued and either dismissed or ignored.

I finally was able to find a doctor (out of pocket, which slowed my progress as i had to pay for treatment navigating it as i could and through deductive reasoning and tedious one factor at a time methodology, selective treatment attempts based on complex models to narrow down to a handful of fungal possibilities (viral and bacterial attempts by previous doctors only made it worse and they refused to consider fungal or parasitic possibilities due to lack of experience and limited treatment options.

In addition to insurance denying any further testing as each type has complex highly specific and limited availability due to the specialization and experience required to read results and interpret the tests) But with a keen Dr I was able to narrow down to 5 possible fungal types and was put on Terbinafine.

I am thrilled beyond belief and having years if such low expectations and the terrible journey I cant even begin to explain. I am on it just into my 2nd month and am showing evidence at least that
i know i am not crazy or grabbing at straws anymore. I have objective evidence to show that its definitely fungal and it spread horribly and resistance is a battle. I can understand the problem and do all possible to fight back now.

I take 250mg a day in addition to twice a day topicals that help with the resistance. I have a long road but am seeing progress in that the rash is starting to diminish and not just the symptoms or masking. Its gross but i can see stuff emerging out and now that i know blisters contain spores and can cause spreading and contamination in the household that has helped as well.

I experimented with the topicals and found which ones seem to cause a reaction (whether it was fungus dying off, it fighting or releasing nasty stuff it was obviously visible. Clotrimazole had initial slowing and the others didn't do anything.

But after taking the oral i find that the fungus is more "unprotected" if that makes sense. Its not encased or inflamed and the topicals are doing much more now.

The combination of Ketoconazol cream and alternating Clotrimazole and Tolnaftate am and pm daily is doing well. I also added a sulfer shower treatment that stays in skin for 5 mins 2 times a week in the shower and that has really accelerated the results.

I have to keep the skin very dry and particular the feet. But understanding the source now was made me more aware if my environment, cleaning habits and airing. I still have a lot of unanswered questions but there is little support and resources available.

This is unfortunate. As a scientist i have documented most if my research and follow very rigid and vital methodology that is accepted in most industries except medical, and find the practices for this beyond negligent. The lack of discipline and data integrity as well as mathematically valid practices for research and testing, i am surprised any research here is capable of valid conclusions.

But i digress. Hopefully this changes but for me i wasn't going to sit by and let a rude doctor tell me i was imagining my symptoms as he ordered ridiculously inconclusive ineffective testing that I could easily read small print invalidating his conclusion of/to eliminate the cause as was a common negative test result, where false negative was suppose to be excluded as it was only a small chance of supportive positive for presence at one specific stage. And clearly not meant to assume negative was to be taken as not. But only to appease my simple mind i guess.

I understand doctors are human and have to try various things but to dismiss a highly likely cause when all other teats and data seem to support it and simply because they are not familiar it doesn't want to be is just unfortunate. I would be better off if i had a better insurance or more experienced doctor but i also feel they caused my problem to worsen and that they didn't care to find out or even give me hope of doing so.

Click here to add your own comments

Join in and write your own page! It's easy to do. How? Simply click here to return to Heart Disease Questions.

Home Privacy Policy Copyright Policy Disclosure Policy Doctors Store

Copyright © 2003 - 2025. All Rights Reserved under USC Title 17. Do not copy
content from the pages of this website without our expressed written consent.
To do so is Plagiarism, Not Fair Use, is Illegal, and a violation of the
The Digital Millennium Copyright Act of 1998.