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What kind of anti yeast drug can penetrate the atherosclerotic plaque?

by Tony Lichaa MD
(Lebanon )

I am Dr. Tony Lichaa, a cardiologist. I have treated many patients with unstable angina with the anti yeast drug griseofulvin and registered a surprising result, but some patients do not tolerate it well. Is there any other drug that can penetrate the plaque? Thank you

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May 02, 2022
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by: Dan

Griseofulvin is FDA approved to treat Tinea capitis in the US. Tinea capitis typically affects the scalp and may result in bald patches, dry areas in the scalp, or redness. It is the primary cause of ringworm. Griseofulvin penetrates the cell wall and membrane structure and targets the nucleus of the fungal cell. The only other medication that targets the nucleus, that I know of, is 5-fluorocytosine (5FC).

There are other modes of treatment that have been effective for Tinea capitis that might provide the desired effect. These drugs are terbinafine, itraconazole, and fluconazole; these medications target the membrane responsible for egosterol synthesis which is located just above the nucleus of the fungal cell. Ketoconazole, voriconazole, and posaconazole also target the membrane.

I hope you find the correlation helpful.

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