Over the years I have noticed other websites promoting grapefruit seed
extract as a candida yeast killer. I have also had quite a few people
ask me why I did not recommend it? The answer to that quite frankly is, up until now,
I have never been able to find any medical proof that it actually
worked. I will not recommend any product for yeast that does not have
any real medical studies to back it up. Anyone can say that such and
such works for yeast but I simply will not play that game. I suggest you
demand the same and ask for the real medical proof that it works before
you spend your money.
The studies I have read up until now, suggested that it was the preservatives in the supplements that did the killing. The main preservative in most grapefruit seed extract supplements is none other than potassium sorbate, which I know stops yeast growth dead in its tracks.
In 2005, a couple of college students at California Polytechnic State University did a study on grapefruit seed extract and its effect on candida albicans. In their study they also analyzed the effects of tea tree oil, garlic, by pressing fresh cloves and using the juice; and the iFlora 6 strain brand of probiotic at a dose of 15 billion bacteria on this yeast. The probiotic contained Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus rhamnosus, and Streptococcus thermophilus.
They compared the anti-fungal properties of these natural remedies to the prescription anti-fungal drugs, Miconazole and Amphotericin B. Both of these drugs completely inhibited the growth of the candida at the typical suggested doses after two hours. However, the Amphotericin B inhibited growth for a longer period of time.
The liquid grapefruit seed extract and the Miconazole inhibited the growth of candida equally. It took them both two hours for full inhibition to take effect and the effects lasted for 16 hours.
Tea tree oil basically had no effect at all. People claim that tea tree oil works for them but in light of this study, I suspect that they have bacterial problems and not candida yeast problems.
The probiotic had zero effect. This is not surprising because the typical probiotic contains mostly acidophilus and a few species of bifidobacteriums which never works at this low dose. I've seen stool test results to prove this as well. Probiotic bacteria work by crowding out the candida yeast and they are much more effective if you take something to kill the yeast first. Then the good bacteria will move in and take over the areas where the yeast was, leaving it with no place to go. This is also why I always recommend probiotic doses in the 300 billion or more range, 15 billion is nothing as this study proves.
However, there are probiotic bacteria that have been medically proven to kill candida yeast and I put them in Profase.
The garlic juice extracted from fresh cloves had no inhibitory effect! I have to admit that this surprised me. Based on this study, I suspect the women out there who are inserting garlic cloves into their vagina's and claiming it worked for them, actually had bacterial vaginosis and not yeast.
In 2012, a study involving gse was found to kill S. cerevisiae by inducing cell death in the yeast cells by destruction of the mitochondrial 60 S ribosomal protein. It also prevented the conversion of pantothenic acid to coenzyme A. 1
Another study found it was effective on Candida albicans and 5 of the Candida sp. strains, but was not effective against dermatophytes and moulds. 2
The students in the Cal Poly study used this grapefruit seed extract.
It also comes in a capsule form, but I have found that Paramicrocidin is the most effective capsule form of GSE.
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Any questions about this study or grapefruit seed extract, please feel free to contact me through the contact page of this website.
1. PLoS One. 2012;7(3):e32943. doi: 10.1371/journal.pone.0032943. Epub 2012 Mar 5. A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast.
2. Wiad Parazytol. 2001;47(4):845-9.[Effects of 33% grapefruit extract on the growth of the yeast--like fungi, dermatopytes and moulds].
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