Culturelle Lactobacillus GG, The Scientifically Proven Probiotic That Will Kill Your Yeast, Build Your Immune System, and Help Restore Your Health to Normal
In 1905 Dr. Elie Metchinikoff conducted original research that led to the discovery of the lactobacillus strains of good bacteria. During his research he suggested that consuming lactobacillus rich yogurt could alter the aging process. Consequently, he was responsible for the introduction of L. bulgaricus and Streptococcus thermophilus in yogurt throughout the world.
While his discovery did aid in the treatment of many intestinal disorders including candida yeast infections, it did not achieve the degree of benefit he had thought it would. The reason for this is l. bulgaricus and Streptococcus thermophilus do not repopulate the human intestine since they are not normally found there. However, the study of probiotics and good bacteria for human health was born.
Fast forward to 1985 when Professors Sherwood Gorbach and Barry Goldin from Boston were doing research into lactobacillus species and the human digestive system. They were looking for the ideal probiotic candidate that would satisfy Dr. Metchinikoff’s vision. The criteria they set consisted of:
Through their research they discovered and isolated a lactobacillus strain that was later named Lactobacillus G.G ATCC 53103 that naturally occurs in the digestive tract. Since then Lactobacillus G.G has been the most studied strain of good bacteria in the world.
The Scientific Research Behind Culturelle®
Lactobacillus GG (LGG) has shown promising results in treating diarrhea caused by viruses and bacteria in both adults and children. Measurements of intestinal microflora show that LGG adheres to the intestinal wall during healthy periods as well as during episodes of diarrhea. In addition, LGG improves microflora balance, and normalizes fecal enzyme and short-chain fatty acid levels.
In a study performed on 2000 individuals, many of them children, for preventing and treating acute diarrhea and intestinal infections the results are clear. No harmful effects were observed but LGG did stabilize the mucosal lining of the intestine, prevent diarrhea, and reduced antibiotic caused diarrhea and intestinal lining inflammation in infants and adults.
Childhood diarrhea is very common in developed countries, but more so in developing countries, and often results in death. LGG was effective and recorded in studies from Pakistan, Thailand, Estonia, and Italy for the treatment of childhood diarrhea.
Another study involved two groups of participants that were given 400mg of Erythromycin 3 times a day for 7 days. One group received regular yogurt, the other yogurt containing LGG. The number of bowel movements, diarrhea, frequency of stomach pain, and nausea was less frequent in the group receiving the LGG. 75% of those people also had detectable levels of LGG in their stool proving LGG survived antibiotic attack.
A study in Peru proved that LGG does repopulate the intestine. A rare feat for any conventionally manufactured probiotic.
April 2005 issue of Allergy published a study on 230 infants with atopic eczema/dermatitis and a suspected cows milk allergy. They formed 3 groups and gave each one either LGG, a mixture of four other probiotic strains or a placebo for four weeks. They also eliminated dairy from there diets. At the end of the four weeks they reintroduced cows milk proving 120 of the infants were allergic to cows milk. The researchers concluded, “Treatment with LGG may alleviate atopic eczema/dermatitis syndrome symptoms in IgE-sensitized infants but not in non-IgE-sensitized infants.” In an earlier study of infants with atopic eczema/dermatitis and allergies, the same researchers concluded that LGG treatment might alleviate intestinal inflammation in infants with atopic eczema/dermatitis syndrome and cow’s milk allergy.
Researchers in Italy measured a marker of intestinal inflammation in 30 children with cystic fibrosis. They also measured the marker in 15 children with active inflammatory bowel disease (IBD) and in 30 healthy controls. Ten of the children with cystic fibrosis received LGG and then the inflammatory marker was measured again four weeks later. According to the researchers, “Intestinal inflammation is a major feature of cystic fibrosis and is reduced by probiotics. The latter finding suggests that intestinal microflora play a major role in intestinal inflammation in cystic fibrosis children.”
An animal study suggested that LGG increased the effectiveness of Glutathione S-transferases (GSTs) to protect the body against harmful compounds and environmental toxins.
A study was done on rats with rheumatoid arthritis. They divided the animals into six groups and fed them either heat-killed Lactobacillus GG, live LGG, sterilized milk, plain yogurt, yogurt-containing LGG, or sterilized water. The researchers concluded, “Our observation of the remarkable preventive and curative effect on arthritis using commercial yogurts containing lactobacilli, especially LGG, suggests the need for investigation of these agents in arthritic patients.”
Many in vitro studies have shown that various types of the lactobacilli friendly bacteria inhibit or kill H. pylori and prevent its adhesion to cells. In vivo models have demonstrated that pre-treatment with a probiotic can prevent H. pylori infections. Studies also have shown that administration of probiotics markedly reduces an existing infection. The study also showed that patients given LGG while taking modern prescription drugs for h pylori tolerated the drugs much better than those that don’t.
Japanese researchers explored another possible effect of Lactobacillus GG. They induced diabetes in rats, then fed the animals LGG or a control diet from nine to 18 weeks of age. Lactobacillus GG not only lowered levels of glycosylated hemoglobin, it also improved glucose tolerance in the animals.
Probiotics such as Lactobacillus GG, Bifidobacterium, and Lactobacillus acidophilus significantly reduce the amount of pathogenic bacteria that inhabit the nasal passages, according to a recent study. According to the researchers, the results indicate that regular intake of probiotics can reduce potentially pathogenic bacteria in the upper respiratory tract. The results also indicate a linkage of the lymphoid tissue between the gut and the upper respiratory tract.
According to a new study, consuming a dietary supplement containing probiotic bacteria plus vitamins and minerals for at least three months may reduce the incidence and the severity of common cold and flu symptoms. According to the researchers, “These data indicate that the intake of a dietary supplement containing probiotic bacteria plus vitamins and minerals during a period of at least three months in winter/spring may reduce the incidence and the severity of symptoms in common cold infections in otherwise healthy adults. This may be due to stimulated cellular immunity.”
Researchers in Finland have discovered that giving probiotics to pregnant and lactating mothers increased the immunoprotective potential of breast milk and protected the infants against atopic eczema during the first 2 years of life.
The fact that it survives antibiotic attack also is a blessing for every woman on the planet that has ever, or will ever, take an antibiotic for anything again. This would be a great probiotic to take with an antibiotic and after so you didn’t get a yeast infection to start with.
The suggested dose would be 3 capsules a day for one week. For the second week take 2 capsules 2 x a day. The third week take 3 capsules 3 x a day for 30 days. After this protocol you could take 1 or 2 capsules a day for maintenance and long term prevention of relapse.
Lactobacillus GG has one drawback. The product does not contain any bifidobacterium species, the most prevalent strain of bacteria in the human intestine. None-the-less, the research and proven benefits of Lactobacillus GG are impressive.
Any questions about Culturelle® Lactobacillus GG? Feel free to contact me from the contact page.
Viljanen M, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy 2005, Apr;60(4):494-500.
Viljanen M, Kuitunen M, Haahtela T, Juntunen-Backman K, Korpela R, Savilahti E. Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants. Pediatr Allergy Immunol 2005, Feb;16(1):65-71.
Bruzzese E, Raia V, Gaudiello G, Polito G, Buccigrossi V, Formicola V, Guarino A. Intestinal inflammation is a frequent feature of cystic fibrosis and is reduced by probiotic administration. Aliment Pharmacol Ther 2004, Oct 1;20(7):813-9.
Edalat M, Mannervik B, Axelsson LG. Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria. Histochem Cell Biol 2004, Aug;122(2):151-9.
Baharav E, Mor F, Halpern M, Weinberger A. Lactobacillus GG bacteria ameliorate arthritis in Lewis rats. J Nutr 2004, Aug;134(8):1964-9.
Hamilton-Miller JM. The role of probiotics in the treatment and prevention of Helicobacter pylori infection. Int J Antimicrob Agents 200,3 Oct;22(4):360-6.
Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, Nista EC, Cammarota G, Gasbarrini G, Gasbarrini A. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 2002 Nov;97(11):2744-9.
Tabuchi M, Ozaki M, Tamura A, Yamada N, Ishida T, Hosoda M, Hosono A. Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 2003, Jun;67(6):1421-4.
Finegold SM, Attebery HR, Sutter VL. Effect of diet on human fecal flora: Comparison of Japanese and American Diets. Am J Clin Nutr 1974;27:1546-69
Moore WEC, Holderman LV. Human fecal flora: Comparison of Japanese and American diets. Appl Microbiol 1974;27:961-79.
Heyman M, Gorthier G, Petit A, Meslin J-C, Moreau C, Desjeux J-F. Intestinal absorption of macromolecules during viral enteritis: An experimental study on rotavirus-infected conventional and germ-free mice. Pediatr Res 19887; 22:72-8.
Heyman M, Grasset E, Duroc R, Desjeux JF. Antigen absorption by the jejunal epithelium of children with cow’s milk allergy. Pediatr Res 1988;24:197-202
Majamaa H, Isolauri E. Evaluation of gut mucosal barrier: Evidence for increased antigen transfer in children with atopic eczema. J Allergy Clin Immunol 1996;97:985-90.
Kaila M, Isolauri E, Soppi E, Virtanen E, Laine S, Arvilommi H. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res 1992;32:141-4.
Isolauri E, Majamaa H, Arvola T, Rantala I, Virtantn E, Arvilommi H. Lactobacillus casei strain GG reverses increased intestinal permeability induced by cow milk in suckling rats. Gastroenterology 1993;105:1643-50.
Hoskins LC, Augustines M, McKee WB, Boulding ET, Kriaris M, Niedermeyer G. Mucin degradation in human colon ecosystems: Isolation and properties of fecal strains that degrade ABH blood group antigens and oligosaccharides from mucin glycoproteins. J Clin Invest 1985;75:977-53.
Coconnier MH, Klaenhammer TR, Kerneis S, Bernet MF, Servin A. Protein-www.ed adhesion of Lactobacillus acidophilus BG2F04 on human enterocyte and mucus-secreting cell lines in culture. Appl Environ Microbiol 1992;58:2034-9.
Elo S, Saxelin M, Salminen S. Attachment of Lactobacillus casei strain GG to human colon carcinoma cell line Caco-2: Comparison with other dairy strains. Lett Appl Microbiol 1991;13:154-6
Goldin B, Gualtieri L, Moore R. The effect of feeding Lactobacillus GG on the initiation and promotion of dimethylhydrazine-induced intestinal tumors in the rat. Nutr Cancer 1996;25:197-204.
Namji AA, Khettry U, Sadrzadeh S. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease. Proc Soc Exp Biol Med 1994;205:243-7.
Millar MR, Bacon C, Smith SL, Walker V, Hall MA. Enteral feeding of premature infants with Lactobacillus GG. Arch Dis Child 1993;69:483-7
Seep E, Mikelsaar M, Salminen S. Effect of administration of Lactobacillus casei strain GG on the gastrointestinal microbiota of newborns. Microbial Ecol Health Dis 1993;6:309-14.
Majamaa H, Isolauri E, Saxelin M, Vesikari T. Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr 1995;20:333-8.
Isolauri E, Juntunen M, Rautanen T, Sillanaukee P, Koivula T. A human Lactobacillus strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children. Pediatrics 1991;88:90-7.
Sheen P, Oberhelman RA, Gilman RH, Cabrera L, Versategui M, Madico G. Short report: a placebo-controlled study of Lactobacillus GG colonization in one- to three-year-old Peruvian children. Am J Trop Med Hyg 1995;52-389-92.
Biller JA, Katz AJ, Flores AF, Buie TM, Gorbach SL. Treatment of recurrent Clostridium difficile colitis with Lactobacillus GG. J Pediatr Gastroenterol Nutr 1995;21:224-6.
Winkler P, de Vrese M, Laue Ch, Schrezenmeir J. Effect of a dietary supplement containing probiotic bacteria plus vitamins and minerals on common cold infections and cellular immune parameters. Int J Clin Pharmacol Ther. 2005 Jul;43(7):318-26.
Rautava S, Kalliomaki M, Isolauri E. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J Allergy Clin Immunol. 2002;109(1):119-21.
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